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504746 Idazoxan Hydrochloride - CAS 79944-56-2 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(1,4-Benzodioxan-2-yl)-2-imidazoline hydrochloride, RX781094, Idazoxa, α₂-Adrenoceptor Antagonist, Idazoxan Hydrochloride

Primary Target: →₂-adrenoceptor
504746
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
79944-56-2C₁₁H₁₂N₂O₂ • HCl

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      Description
      OverviewA non-selective antagonist for α2-adrenoceptors (pKi = 8.01, 7.43, and 7.7 for α2A, α2B, and α2C receptors respectively) and imidazoline receptors. (pKi = 5.90, 7.22 for I1 and I2, receptors respectively). Widely used in studying functions of the nervous systems, such as learning and memory, decision making, reward, attention, addiction, depression, and schizophrenia related to the adrenergic receptors, and blood pressure regulation, pain modulation, and neuroprotection related to the imidazoline receptors.
      Catalogue Number504746
      Brand Family Calbiochem®
      Synonyms2-(1,4-Benzodioxan-2-yl)-2-imidazoline hydrochloride, RX781094, Idazoxa, α₂-Adrenoceptor Antagonist, Idazoxan Hydrochloride
      References
      ReferencesHumpston, S., et al. 2013. J. of Psychopharmacology, 27, 213.
      Dabir, l., 1986. J.Pharmacol. 17, 113.
      Michel, M., et al. 1992. TIPS 13, 369.
      Eglen, R., et al. 1998. TiPS 19, 381.
      Doxey, J., et al. 1984. Br J Pharmacol. 1984. 83, 713.
      Gadie, B., 1984. Br J Pharmacol. 83, 707.
      Product Information
      CAS number79944-56-2
      FormWhite powder
      Hill FormulaC₁₁H₁₂N₂O₂ • HCl
      Chemical formulaC₁₁H₁₂N₂O₂ • HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target→₂-adrenoceptor
      Purity≥98% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 25

      Toxic if swallowed.
      S PhraseS: 22-36-45

      Do not breathe dust.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Idazoxan Hydrochloride - CAS 79944-56-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Humpston, S., et al. 2013. J. of Psychopharmacology, 27, 213.
      Dabir, l., 1986. J.Pharmacol. 17, 113.
      Michel, M., et al. 1992. TIPS 13, 369.
      Eglen, R., et al. 1998. TiPS 19, 381.
      Doxey, J., et al. 1984. Br J Pharmacol. 1984. 83, 713.
      Gadie, B., 1984. Br J Pharmacol. 83, 707.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-May-2013 JSW
      Synonyms2-(1,4-Benzodioxan-2-yl)-2-imidazoline hydrochloride, RX781094, Idazoxa, α₂-Adrenoceptor Antagonist, Idazoxan Hydrochloride
      DescriptionA non-selective antagonist for ?2-adrenoceptors (pKi = 8.01, 7.43, and 7.7 for ?2A, ?2B, and ?2C receptors respectively) and imidazoline receptors. (pKi = 5.90, 7.22 for I1 and I2, receptors respectively). Widely used in studying functions of the nervous systems, such as learning and memory, decision making, reward, attention, addiction, depression, and schizophrenia related to the adrenergic receptors, and blood pressure regulation, pain modulation, and neuroprotection related to the imidazoline receptors.
      FormWhite powder
      CAS number79944-56-2
      Chemical formulaC₁₁H₁₂N₂O₂ • HCl
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityH₂O (50 mg/ml)
      Storage +15°C to +30°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      ReferencesHumpston, S., et al. 2013. J. of Psychopharmacology, 27, 213.
      Dabir, l., 1986. J.Pharmacol. 17, 113.
      Michel, M., et al. 1992. TIPS 13, 369.
      Eglen, R., et al. 1998. TiPS 19, 381.
      Doxey, J., et al. 1984. Br J Pharmacol. 1984. 83, 713.
      Gadie, B., 1984. Br J Pharmacol. 83, 707.