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Description
Overview
A non-selective antagonist for α2-adrenoceptors (pKi = 8.01, 7.43, and 7.7 for α2A, α2B, and α2C receptors respectively) and imidazoline receptors. (pKi = 5.90, 7.22 for I1 and I2, receptors respectively). Widely used in studying functions of the nervous systems, such as learning and memory, decision making, reward, attention, addiction, depression, and schizophrenia related to the adrenergic receptors, and blood pressure regulation, pain modulation, and neuroprotection related to the imidazoline receptors.
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Product Usage Statements
Storage and Shipping Information
Ship Code
Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity
Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+15°C to +30°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Documentation
Idazoxan Hydrochloride - CAS 79944-56-2 - Calbiochem SDS
Humpston, S., et al. 2013. J. of Psychopharmacology, 27, 213. Dabir, l., 1986. J.Pharmacol.17, 113. Michel, M., et al. 1992. TIPS13, 369. Eglen, R., et al. 1998. TiPS19, 381. Doxey, J., et al. 1984. Br J Pharmacol. 1984. 83, 713. Gadie, B., 1984. Br J Pharmacol.83, 707.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A non-selective antagonist for ?2-adrenoceptors (pKi = 8.01, 7.43, and 7.7 for ?2A, ?2B, and ?2C receptors respectively) and imidazoline receptors. (pKi = 5.90, 7.22 for I1 and I2, receptors respectively). Widely used in studying functions of the nervous systems, such as learning and memory, decision making, reward, attention, addiction, depression, and schizophrenia related to the adrenergic receptors, and blood pressure regulation, pain modulation, and neuroprotection related to the imidazoline receptors.
Form
White powder
CAS number
79944-56-2
Chemical formula
C₁₁H₁₂N₂O₂ • HCl
Structure formula
Purity
≥98% by TLC
Solubility
H₂O (50 mg/ml)
Storage
+15°C to +30°C
Protect from light
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Toxic
References
Humpston, S., et al. 2013. J. of Psychopharmacology, 27, 213. Dabir, l., 1986. J.Pharmacol.17, 113. Michel, M., et al. 1992. TIPS13, 369. Eglen, R., et al. 1998. TiPS19, 381. Doxey, J., et al. 1984. Br J Pharmacol. 1984. 83, 713. Gadie, B., 1984. Br J Pharmacol.83, 707.