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531237 IRAK4 Inhibitor, Compound 26 - CAS 1604034-71-0 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1604034-71-0C₂₅H₂₇N₅O₂

Products

Catalog NumberPackaging Qty/Pack
5.31237.0001 Glass bottle 10 mg
Description
OverviewA cell permeable indolo[2,3-c]quinoline derivatived compound that acts as a selective and highly potent inhibitor of interleukin-1 receptor associated kinase (IRAK4; IC50 = 94 pM). Displays much reduced potency against IRAK1 (IC50 = 65 nM) and displays high selectivity over a panel of other 27 kinases, including several involved in TLR-mediated signaling. Blocks R848-induced TNF-α and IL-6 production in primary human monocytes and inhibits LPS-induced TNF-α production in mice (100 mpk). Shows minimal inhibition of Cyp2C9, 2D6, and 3A4 and has excellent microsomal stability and desirable aqueous solubility (100 μg/ml at pH 7.4).

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number531237
Brand Family Calbiochem®
SynonymsInterleukin-1 Receptor Associated Kinase 4 Inhibitor
References
ReferencesTumey, L.N., et al. 2014 Bioorg. Med. Chem. Lett. 24, 2066.
Product Information
CAS number1604034-71-0
FormPale yellow powder
Hill FormulaC₂₅H₂₇N₅O₂
Chemical formulaC₂₅H₂₇N₅O₂
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetIRAK4
Primary Target IC<sub>50</sub>94 pM
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.31237.0001 04055977242706

Documentation

IRAK4 Inhibitor, Compound 26 - CAS 1604034-71-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Tumey, L.N., et al. 2014 Bioorg. Med. Chem. Lett. 24, 2066.

Brochure

Title
NPI Flyer- Epigenetics and Nuclear Function Feature
New Products - Antibodies, Small Molecule, Inhibitors

Technical Info

Title
White Paper: Further considerations of antibody validation and usage.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-August-2017 JSW
SynonymsInterleukin-1 Receptor Associated Kinase 4 Inhibitor
DescriptionA cell permeable indolo[2,3-c]quinoline derivatived compound that acts as a selective and highly potent inhibitor of interleukin-1 receptor associated kinase (IRAK4; IC50 = 94 pM). Displays much reduced potency against IRAK1 (IC50 = 65 nM) and displays high selectivity over a panel of other 27 kinases, including several involved in TLR-mediated signaling. Blocks R848-induced TNF-α and IL-6 production in primary human monocytes and inhibits LPS-induced TNF-α production in mice (100 mpk). Shows minimal inhibition of Cyp2C9, 2D6, and 3A4 and has excellent microsomal stability and desirable aqueous solubility (100 μg/ml at pH 7.4).
FormPale yellow powder
Intert gas (Yes/No) Packaged under inert gas
CAS number1604034-71-0
Chemical formulaC₂₅H₂₇N₅O₂
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTumey, L.N., et al. 2014 Bioorg. Med. Chem. Lett. 24, 2066.