504361 INCB 3284 Dimesylate - CAS 887401-93-6 - Calbiochem

504361
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Overview

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Key Specifications Table

Empirical FormulaCAS #
C₂₆H₃₁F₃N₄O₄•2CH₄O₃ 887401-93-6

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      Glass bottle 5 mg
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      Description
      OverviewA potent and highly selective human CCR2 (hCCR2) antagonist (IC50 = 3.7 nM, 4.7 nM, and 84 nM for monocyte chemoattractant protein-1 binding to hCCR2, chemotaxis activity, inhibition of the hERG potassium current, respectively).
      Catalogue Number504361
      Brand Family Calbiochem®
      Synonyms N-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide dimethanesulfonate, INCB 3284, INCB3284
      References
      ReferencesXia, M., et al. 2009. Expert Opinion on Therapeutic Patents. 19, 295.
      Xue, C., et al. 2011. ACS Med. Chem. Lett. 2, 450.
      Product Information
      CAS number887401-93-6
      FormOff-white solid
      Hill FormulaC₂₆H₃₁F₃N₄O₄•2CH₄O₃
      Chemical formulaC₂₆H₃₁F₃N₄O₄•2CH₄O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targethuman CCR2 (hCCR2)
      Primary Target IC<sub>50</sub>3.7 nM, 4.7 nM, and 84 nM for different assays.
      Purity≥98% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze 9-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      INCB 3284 Dimesylate - CAS 887401-93-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Xia, M., et al. 2009. Expert Opinion on Therapeutic Patents. 19, 295.
      Xue, C., et al. 2011. ACS Med. Chem. Lett. 2, 450.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-July-2013 JSW
      Synonyms N-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide dimethanesulfonate, INCB 3284, INCB3284
      DescriptionA potent and highly selective human CCR2 (hCCR2) antagonist (IC50 = 3.7 nM, 4.7 nM, and 84 nM for monocyte chemoattractant protein-1 binding to hCCR2, chemotaxis activity, inhibition of the hERG potassium current, respectively).
      FormOff-white solid
      CAS number887401-93-6
      Chemical formulaC₂₆H₃₁F₃N₄O₄•2CH₄O₃
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (12 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze 9-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesXia, M., et al. 2009. Expert Opinion on Therapeutic Patents. 19, 295.
      Xue, C., et al. 2011. ACS Med. Chem. Lett. 2, 450.