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407256 IGF-II, CF, Mouse, Recombinant

407256
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Overview

Replacement Information

Key Specifications Table

Purity
≥97% by SDS-PAGE

Pricing & Availability

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407256-50UG
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      Description
      OverviewRecombinant, mouse insulin-like growth factor II (IGF-II) consisting of amino acids 25-91 and expressed in E. coli. Mouse IGF-II is synthesized as a 180 amino acid preproprecursor. Mature IGF-II is 91% and 97% amino acid identical to human and rat IGF-II, respectively.
      Catalogue Number407256
      Brand Family Calbiochem®
      SynonymsMultiplication-stimulating polypeptide Somatomedin A
      References
      ReferencesOstrovsky, O., et al. 2009. Mol. Biol. Cell 20, 1855.
      Chao, W. & P. A. DAmore, 2008. Cytokine Growth Factor Rev. 19, 111.
      Belfiore, A., 2007. Curr. Pharm. Des. 13, 671.
      Cornish, J., et al. 2007. Am. J. Physiol. Endocrinol. Metab. 292,E117.
      Merrick, D., et al. 2007. BMC Dev. Biol. 7, 65.
      Pavelic, J., et al. 2007. Indian J. Med. Res. 125, 511.
      VarelaNieto, I., et al. 2007. Curr. Pharm. Des. 13,687.
      Denley, A. et al. 2005. Cytokine Growth Factor Re,v. 16, 421.
      LeRoith, D. & C.T. Roberts Jr., 2003. Cancer Lett. 195,127.
      Buchanan, C.M., et al. 2001. Biochem. J. 360, 431.
      Werner, H. & D. LeRoith, 2000. Cell. Mol. Life Sci. 57, 932.
      Goya, L., et al. 1999. J. Biol. Chem. 274 24633.
      Daughaday, W.H., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 5823.
      Holthuizen, P.E., et al. 1993. Regul. Pept. 48, 77.
      McCarthy, T.L., et al. 1992. Endocrinology 130, 1303.
      Zindy, F., et al. 1992. J. Hepatol. 14, 30.
      Rotwein, P. & L.J. Hall, 1990. DNA Cell Biol. 10,725.
      Rotwein, P., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 265.
      Stempien, M.M., et al. 1986. DNA 5, 357.
      Product Information
      FormSolid
      FormulationLyophilized from 0.2 µm sterile-filtered Acetonitrile, TFA.
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityED₅₀ = 2-10 ng/ml as measured in a serum-free cell proliferation assay using MCF-7 human breast adenocarcinoma cells.
      Purity≥97% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: <1.0 EU/µg protein
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      IGF-II, CF, Mouse, Recombinant SDS

      Title

      Safety Data Sheet (SDS) 

      IGF-II, CF, Mouse, Recombinant Certificates of Analysis

      TitleLot Number
      407256

      References

      Reference overview
      Ostrovsky, O., et al. 2009. Mol. Biol. Cell 20, 1855.
      Chao, W. & P. A. DAmore, 2008. Cytokine Growth Factor Rev. 19, 111.
      Belfiore, A., 2007. Curr. Pharm. Des. 13, 671.
      Cornish, J., et al. 2007. Am. J. Physiol. Endocrinol. Metab. 292,E117.
      Merrick, D., et al. 2007. BMC Dev. Biol. 7, 65.
      Pavelic, J., et al. 2007. Indian J. Med. Res. 125, 511.
      VarelaNieto, I., et al. 2007. Curr. Pharm. Des. 13,687.
      Denley, A. et al. 2005. Cytokine Growth Factor Re,v. 16, 421.
      LeRoith, D. & C.T. Roberts Jr., 2003. Cancer Lett. 195,127.
      Buchanan, C.M., et al. 2001. Biochem. J. 360, 431.
      Werner, H. & D. LeRoith, 2000. Cell. Mol. Life Sci. 57, 932.
      Goya, L., et al. 1999. J. Biol. Chem. 274 24633.
      Daughaday, W.H., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 5823.
      Holthuizen, P.E., et al. 1993. Regul. Pept. 48, 77.
      McCarthy, T.L., et al. 1992. Endocrinology 130, 1303.
      Zindy, F., et al. 1992. J. Hepatol. 14, 30.
      Rotwein, P. & L.J. Hall, 1990. DNA Cell Biol. 10,725.
      Rotwein, P., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 265.
      Stempien, M.M., et al. 1986. DNA 5, 357.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-Sepmtember-2011 RFH
      SynonymsMultiplication-stimulating polypeptide Somatomedin A
      DescriptionRecombinant, mouse insulin-like growth factor II (IGF-II) consisting of amino acids 25-91 and expressed in E. coli. Mouse IGF-II is synthesized as a 180 amino acid preproprecursor. Mature IGF-II is 91% and 97% amino acid identical to human and rat IGF-II, respectively.
      FormSolid
      FormulationLyophilized from 0.2 µm sterile-filtered Acetonitrile, TFA.
      Purity≥97% by SDS-PAGE
      ContaminantsEndotoxin: <1.0 EU/µg protein
      Biological activityED₅₀ = 2-10 ng/ml as measured in a serum-free cell proliferation assay using MCF-7 human breast adenocarcinoma cells.
      SolubilityReconstitute to 100 µg/ml in sterile PBS.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesOstrovsky, O., et al. 2009. Mol. Biol. Cell 20, 1855.
      Chao, W. & P. A. DAmore, 2008. Cytokine Growth Factor Rev. 19, 111.
      Belfiore, A., 2007. Curr. Pharm. Des. 13, 671.
      Cornish, J., et al. 2007. Am. J. Physiol. Endocrinol. Metab. 292,E117.
      Merrick, D., et al. 2007. BMC Dev. Biol. 7, 65.
      Pavelic, J., et al. 2007. Indian J. Med. Res. 125, 511.
      VarelaNieto, I., et al. 2007. Curr. Pharm. Des. 13,687.
      Denley, A. et al. 2005. Cytokine Growth Factor Re,v. 16, 421.
      LeRoith, D. & C.T. Roberts Jr., 2003. Cancer Lett. 195,127.
      Buchanan, C.M., et al. 2001. Biochem. J. 360, 431.
      Werner, H. & D. LeRoith, 2000. Cell. Mol. Life Sci. 57, 932.
      Goya, L., et al. 1999. J. Biol. Chem. 274 24633.
      Daughaday, W.H., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 5823.
      Holthuizen, P.E., et al. 1993. Regul. Pept. 48, 77.
      McCarthy, T.L., et al. 1992. Endocrinology 130, 1303.
      Zindy, F., et al. 1992. J. Hepatol. 14, 30.
      Rotwein, P. & L.J. Hall, 1990. DNA Cell Biol. 10,725.
      Rotwein, P., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 265.
      Stempien, M.M., et al. 1986. DNA 5, 357.