01-189 IGF-I, somatomedins, insulin-like growth factors (resistant to IGFBPs)

01-189
25 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Key ApplicationsSpeciesSource
      CULT Human Recombinant human IGF-I (ER3) expressed in E. coli
      Description
      Catalogue Number01-189
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionIGF-I, somatomedins, insulin-like growth factors (resistant to IGFBPs)
      References
      Product Information
      PresentationLypholized from acetic acid
      Quality LevelMQ100
      Applications
      ApplicationThe IGF-I protein, somatomedins, insulin-like growth factors (resistant to IGFBPs) is available in a 25 µg format.
      Key Applications
      • Cell Culture
      Biological Information
      SourceRecombinant human IGF-I (ER3) expressed in E. coli
      Entrez Gene Number
      Entrez Gene SummaryThe somatomedins, or insulin-like growth factors (IGFs), comprise a family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone (GH; MIM 139250). Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin' (Daughaday et al., 1972 [PubMed 4550398]). Three main somatomedins have been characterized: somatomedin C (IGF1), somatomedin A (IGF2; MIM 147470), and somatomedin B (MIM 193190) (Rotwein, 1986 [PubMed 3455760]; Rosenfeld, 2003 [PubMed 14657423]).[supplied by OMIM]
      Gene Symbol
      • IGF1
      • IBP1
      • IGFI
      • IGF-IA
      • MGF
      • IGF-IB
      Purification MethodSterilized through a 0.2 micron membrane filter
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P05019 # The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.| P01343 # The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.
      SIZE: 195 amino acids; 21841 Da
      SUBCELLULAR LOCATION: Secreted.
      DOMAIN: SwissProt: P05019
      DISEASE: SwissProt: P05019 # Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.| P01343 # Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
      SIMILARITY: SwissProt: P05019 ## Belongs to the insulin family.| P01343 ## Belongs to the insulin family.
      Stem Cell Type
      • Neural Stem Cells
      • Epithelial Cells
      • Mesenchymal Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated in a biological activity assay.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size25 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      IGF-I, somatomedins, insulin-like growth factors (resistant to IGFBPs) Certificates of Analysis

      TitleLot Number
      IGF-I (resistant to IGFBPs) (recombinant protein expressed in E. coli) - 21473212147321
      IGF-I (resistant to IGFBPs) (recombinant protein expressed in E. coli)3016920
      IGF-I (resistant to IGFBPs) (recombinant protein expressed in E. coli)2884078
      IGF-I (resistant to IGFBPs) (recombinant protein expressed in E. coli) - 20748792074879
      IGF-I (resistant to IGFBPs) (recombinant protein expressed in E. coli) - 22778362277836
      IGF-I (resistant to IGFBPs) (recombinant protein expressed in E. coli) - 23687202368720
      IGF-I (resistant to IGFBPs) (recombinant protein expressed in E. coli) - DAM1774655DAM1774655
      IGF-I (resistant to IGFBPs) (recombinant protein expressed in E. coli) -24855662485566
      IGF-I (resistant to IGFBPs) - 1590515905
      IGF-I (resistant to IGFBPs) - 1840218402

      References

      Reference overviewApplicationPub Med ID
      Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A.
      Fang, X, et al.
      Proc. Natl. Acad. Sci. U.S.A., 97: 11960-5 (2000)  2000

      Show Abstract
      Cell Culture11035810 11035810
      Insulin-like growth factors.
      LeRoith, D and Roberts, C T
      Ann. N. Y. Acad. Sci., 692: 1-9 (1993)  1993

      Show Abstract
      8215015 8215015
      Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency.
      Francis, G L, et al.
      J. Mol. Endocrinol., 8: 213-23 (1992)  1992

      Show Abstract
      1378742 1378742

      Related Products & Applications

      Product Families

      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors