Product Information
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 36/37/39

Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Hydroxychloroquine Sulfate - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Kim, J., et al. 2012. PLoS ONE. 7, e31004.
Ramser, B., et al. 2009. J. Invest. Dermatol. 129, 2419.
Boya., P., et al. 2005. Mol. Cell. Biol. 22, 1025.
Oikarinen, A., et al. 2009. J. Invest. Dermatol. 129, 2333.
Kuznik, A., et al. 2011. J. Immunol. 186, 4794.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-February-2014 JSW
SynonymsHCQ, Autophagy Inhibitor
DescriptionA cell-permeable, orally available quinoline derivative with anti-malarial properties. Increases intralysosomal pH and thereby impairs autophagic degradation process. Reduces metabolic activity and suppresses proliferation of human dermal fibroblasts (IC50 = 30 µM). Shown to inhibit ERK1/2 phosphorylation (Thr202/Try204), but does not affect Akt and mTOR phosphorylation. Shown to directly block the binding of CXCL12 to CXCR4 and inhibit downstream effects in pancreatic cancer cells (EC50 = 9.8 µM). Effectively antagonizes CXCR4-mediated cell proliferation in PANC-1, Hs-766T, and MIAPaCa-2 cells. Suppresses Toll-like receptor 9 (TLR-9)-mediated dendritic cell activation and displays anti-inflammatory properties.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₈H₂₈ClN₃O₅S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (100 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesKim, J., et al. 2012. PLoS ONE. 7, e31004.
Ramser, B., et al. 2009. J. Invest. Dermatol. 129, 2419.
Boya., P., et al. 2005. Mol. Cell. Biol. 22, 1025.
Oikarinen, A., et al. 2009. J. Invest. Dermatol. 129, 2333.
Kuznik, A., et al. 2011. J. Immunol. 186, 4794.

Related Products & Applications

Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Autophagy Inhibitors