Product Information
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem Certificates of Analysis

TitleLot Number
382175

References

Reference overview
Kozikowski, A.P., et al. 2008. J. Med. Chem. 51, 4370.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-November-2010 JSW
SynonymsN-(4-(3-(((7-Hydroxyamino-7-oxoheptyl)amino)carbonyl)-5-isoxazolyl)phenyl)-1,1-dimethylethylester, carbamic acid, HDAC Inhibitor VIII
DescriptionA cell-permeable, active site Zn2+-targeting phenylisoxazolo-hydroxamate that acts a potent and highly selective HDAC6 inhibitor (IC50 = 0.002, 0.42, 90.7, 252, 271 and 6851 nM against HDAC-6, -3, -10, -2, -1 and -8, respectively). Shown to be more potent than SAHA in inhibiting the proliferation of a panel of pancreatic cancer cell lines (IC50 <1.0 µM).
FormBeige to light brown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1045792-66-2
Chemical formulaC₂₂H₃₀N₄O₆
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesKozikowski, A.P., et al. 2008. J. Med. Chem. 51, 4370.

Related Products & Applications

Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Histone Acetylase and Deacetylase Inhibitors