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382170 Histone Deacetylase Inhibitor IV - CAS 537034-15-4 - Calbiochem

382170
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
537034-15-4C₁₉H₂₃N₃O₂

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382170-10MG
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      Plastic ampoule 10 mg
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      Description
      OverviewA cell-permeable pimeloylanilide compound that acts as a FXN- (frataxin gene) specific HDAC (histone deacetylase) inhibitor. Reverses the silencing of FXN transcription in FRDA (Friedreich's ataxia) cells (~3-fold increase of FXN mRNA at 5 µM in primary FRDA lymphocytes and ~3-fold frataxin expression in FRDA cell line at 2.5 µM) due to hypoacetylation of histones H3 and H4 by increasing acetylation at H3K14, H4K5 and H4K12, without significant changes in acetylation at H3K9, H4K8 and H4K16. In comparison, Trichostatin-A (Cat. No. 647925 and 647926) and SAHA, two other commonly used HDAC inhibitors, exhibit no effect on FXN transcription.
      Catalogue Number382170
      Brand Family Calbiochem®
      SynonymsN¹-(2-Aminophenyl)-N⁷-phenylheptanediamide
      References
      ReferencesHerman, D., et al. 2006. Nat. Chem. Biol. 2, 551.
      Product Information
      CAS number537034-15-4
      ATP CompetitiveN
      FormBeige solid
      Hill FormulaC₁₉H₂₃N₃O₂
      Chemical formulaC₁₉H₂₃N₃O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetHistone Deacetylase
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Histone Deacetylase Inhibitor IV - CAS 537034-15-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Histone Deacetylase Inhibitor IV - CAS 537034-15-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      382170

      References

      Reference overview
      Herman, D., et al. 2006. Nat. Chem. Biol. 2, 551.

      Brochure

      Title
      Biologics 33.2

      Technical Info

      Title
      White Paper - The Message in the Marks: Deciphering Cancer Epigenetics (EMD)
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      SynonymsN¹-(2-Aminophenyl)-N⁷-phenylheptanediamide
      DescriptionA cell-permeable pimeloylanilide compound that acts as a FXN- (frataxin gene) specific HDAC (histone deacetylase) inhibitor. Reverses the silencing of FXN transcription in FRDA (Friedreich's ataxia) cells (~3-fold increase of FXN mRNA at 5 µM in primary FRDA lymphocytes and ~3-fold frataxin expression in FRDA cell line at 2.5 µM) due to hypoacetylation of histones H3 and H4 by increasing acetylation at H3K14, H4K5 and H4K12, without significant changes in acetylation at H3K9, H4K8 and H4K16. In comparison, Trichostatin-A (Cat. No. 647925 and 647926) and SAHA, two other commonly used HDAC inhibitors, exhibit no effect on FXN transcription.
      FormBeige solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number537034-15-4
      Chemical formulaC₁₉H₂₃N₃O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml) or Methanol (5 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful
      ReferencesHerman, D., et al. 2006. Nat. Chem. Biol. 2, 551.