373276 Sigma-AldrichHh Signaling Antagonist XIII, HPI-3 - CAS 796887-98-4 - Calbiochem
The Hh Signaling Antagonist XIII, HPI-3, also referenced under CAS 796887-98-4, controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Cell Signaling applications.
More>> The Hh Signaling Antagonist XIII, HPI-3, also referenced under CAS 796887-98-4, controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Cell Signaling applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 2-((-(4-Phenylpiperazin-4-yl)quinazolin-4-yl)amino)ethanol
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Overview
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Key Specifications Table
Empirical Formula |
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C₂₀H₂₃N₅O |
Pricing & Availability
Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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373276-10MG |
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10 mg |
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Description | |
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Overview | A cell-permeable piperazinyl-quinazoline compound that acts as a downstream Hh (Hedgehog) pathway blocker, effectively inhibiting Gli-dependent transcription activity in both Sufu+/+ NIH 3T3 (shh-LIGHT2) and Sufu-/- fibroblast cultures (IC50 = 3 & 9 µM, respectively) in a manner similar to two other Hh downstream blockers, HPI-1 (Cat. No. 373275) and GANT-61 (Cat. No. 373401). However, unlike HPI-1, HPI-3's inhibitory activity against Su(fu)-/- fibroblasts is completely abolished by Gli1 or Gli2 overexpression. While both HPI-1 and HPI-3 are shown to inhibit the ligand-independent Hh pathway activation in SmoM2-expressing NIH 3T3 cultures (IC50 = 2.5 & 1 µM, respectively), only HPI-1, but not HPI-3, is able to effectively suppress the SmoM2-induced Hh pathway activation in primary murine CGNPs (Cerebellar Granule Neuron Precursors) cultures. |
Catalogue Number | 373276 |
Brand Family | Calbiochem® |
Synonyms | 2-((-(4-Phenylpiperazin-4-yl)quinazolin-4-yl)amino)ethanol |
References | |
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References | Hyman, J.M., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 14132. |
Product Information | |
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CAS number | 796887-98-4 |
Form | Beige solid |
Hill Formula | C₂₀H₂₃N₅O |
Chemical formula | C₂₀H₂₃N₅O |
Structure formula Image | |
Quality Level | MQ100 |
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Purity | ≥95% by HPLC |
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Packaged under inert gas | Packaged under inert gas |
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Documentation
Hh Signaling Antagonist XIII, HPI-3 - CAS 796887-98-4 - Calbiochem SDS
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Hh Signaling Antagonist XIII, HPI-3 - CAS 796887-98-4 - Calbiochem Certificates of Analysis
Title | Lot Number |
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373276 |
References
Reference overview |
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Hyman, J.M., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 14132. |