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373276 Hh Signaling Antagonist XIII, HPI-3 - CAS 796887-98-4 - Calbiochem

The Hh Signaling Antagonist XIII, HPI-3, also referenced under CAS 796887-98-4, controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Cell Signaling applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-((-(4-Phenylpiperazin-4-yl)quinazolin-4-yl)amino)ethanol

373276
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₀H₂₃N₅O 796887-98-4

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373276-10MG
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      Description
      OverviewA cell-permeable piperazinyl-quinazoline compound that acts as a downstream Hh (Hedgehog) pathway blocker, effectively inhibiting Gli-dependent transcription activity in both Sufu+/+ NIH 3T3 (shh-LIGHT2) and Sufu-/- fibroblast cultures (IC50 = 3 & 9 µM, respectively) in a manner similar to two other Hh downstream blockers, HPI-1 (Cat. No. 373275) and GANT-61 (Cat. No. 373401). However, unlike HPI-1, HPI-3's inhibitory activity against Su(fu)-/- fibroblasts is completely abolished by Gli1 or Gli2 overexpression. While both HPI-1 and HPI-3 are shown to inhibit the ligand-independent Hh pathway activation in SmoM2-expressing NIH 3T3 cultures (IC50 = 2.5 & 1 µM, respectively), only HPI-1, but not HPI-3, is able to effectively suppress the SmoM2-induced Hh pathway activation in primary murine CGNPs (Cerebellar Granule Neuron Precursors) cultures.
      Catalogue Number373276
      Brand Family Calbiochem®
      Synonyms2-((-(4-Phenylpiperazin-4-yl)quinazolin-4-yl)amino)ethanol
      References
      ReferencesHyman, J.M., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 14132.
      Product Information
      CAS number796887-98-4
      FormBeige solid
      Hill FormulaC₂₀H₂₃N₅O
      Chemical formulaC₂₀H₂₃N₅O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Hh Signaling Antagonist XIII, HPI-3 - CAS 796887-98-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Hh Signaling Antagonist XIII, HPI-3 - CAS 796887-98-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      373276

      References

      Reference overview
      Hyman, J.M., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 14132.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      Synonyms2-((-(4-Phenylpiperazin-4-yl)quinazolin-4-yl)amino)ethanol
      DescriptionA cell-permeable piperazinyl-quinazoline compound that acts as a downstream Hh (Hedgehog) pathway blocker, effectively inhibiting Gli-dependent transcription activity in both Sufu+/+ NIH 3T3 (shh-LIGHT2) and Sufu-/- fibroblast cultures (IC50 = 3 & 9 µM, respectively) in a manner similar to two other Hh downstream blockers, HPI-1 (Cat. No. 373275) and GANT-61 (Cat. No. 373401). However, unlike HPI-1, HPI-3's inhibitory activity against Su(fu)-/- fibroblasts is completely abolished by Gli1 or Gli2 overexpression. While both HPI-1 and HPI-3 are shown to inhibit the ligand-independent Hh pathway activation in SmoM2-expressing NIH 3T3 cultures (IC50 = 2.5 & 1 µM, respectively), only HPI-1, but not HPI-3, is able to effectively suppress the SmoM2-induced Hh pathway activation in primary murine CGNPs (Cerebellar Granule Neuron Precursors) cultures.
      FormBeige solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number796887-98-4
      Chemical formulaC₂₀H₂₃N₅O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesHyman, J.M., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 14132.