373271 Hec1/Nek2 Mitotic Pathway Inhibitor II, INH6 - CAS 1001753-24-7 - Calbiochem

373271
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Key Specifications Table

Empirical FormulaCAS #
C₁₉H₁₈N₂OS 1001753-24-7

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373271-10MG
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      10 mg
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      Description
      OverviewA cell-permeable INH1 (Cat. No. 373270) analog that contains a tri-, instead of di-, methylated aryl ring and exhibits significantly improved antiproliferative activity against MB231, MB468, HeLa, and K562 cells (IC50 = 1.7, 2.1, 2.4, and 2.5 µM, respectively) than INH1 (IC50 = 8.6, 10.5, 8.8, and 11.7 µM, respectively). Immobilized INH6 is shown to selectively pull down Hec1, but not Nek2, from HeLa cell extract. Treatment of HeLa cultures results in down-regulations of cellular Nek2 (6.25 µM , >4 h) and Hec1 (6.25 µM , >16 h), an increase in apoptotic G1 population (by 10-fold; 2.5 µM, 72 h), as well as increased mitotic abnormalities, including multipolar spindle formations and metaphase chromosome misalignment.
      Catalogue Number373271
      Brand Family Calbiochem®
      SynonymsN-(4-(2,4,6-Trimethylphenyl)-thiazol-2-yl)-benzamide, INH6
      References
      ReferencesQiu, X.L., et al. 2009. J. Med. Chem. 52, 1757.
      Product Information
      CAS number1001753-24-7
      FormWhite solid
      Hill FormulaC₁₉H₁₈N₂OS
      Chemical formulaC₁₉H₁₈N₂OS
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25-36

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing resonstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Hec1/Nek2 Mitotic Pathway Inhibitor II, INH6 - CAS 1001753-24-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Hec1/Nek2 Mitotic Pathway Inhibitor II, INH6 - CAS 1001753-24-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      373271

      References

      Reference overview
      Qiu, X.L., et al. 2009. J. Med. Chem. 52, 1757.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      SynonymsN-(4-(2,4,6-Trimethylphenyl)-thiazol-2-yl)-benzamide, INH6
      DescriptionA cell-permeable INH1 (Cat. No. 373270) analog that contains a tri-, instead of di-, methylated aryl ring and exhibits significantly improved antiproliferative activity against MB231, MB468, HeLa, and K562 cells (IC50 = 1.7, 2.1, 2.4, and 2.5 µM, respectively) than INH1 (IC50 = 8.6, 10.5, 8.8, and 11.7 µM, respectively). Immobilized INH6 is shown to selectively pull down Hec1, but not Nek2, from HeLa cell extract. Treatment of HeLa cultures results in down-regulations of cellular Nek2 (6.25 µM, >4 h) and Hec1 (6.25 µM, >16 h), an increase in apoptotic G1 population (by 10-fold; 2.5 µM, 72 h), as well as increased mitotic abnormalities, including multipolar spindle formations and metaphase chromosome misalignment.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1001753-24-7
      Chemical formulaC₁₉H₁₈N₂OS
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml) or Ethanol (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing resonstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesQiu, X.L., et al. 2009. J. Med. Chem. 52, 1757.