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508313 HSP90α Inhibitor, PU-29F - CAS 422508-27-8 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
422508-27-8C₂₀H₂₆FN₅O₄

Products

Catalog NumberPackaging Qty/Pack
5.08313.0001 Glass bottle 5 mg
Description
OverviewA cell-permeable 6-amino-purine based compound that selectively binds to HSP90a (EC50 = 5.4 µM) and inhibits its activity in SKBr3 and MCF-7 breast cancer cells. Exhibits much reduced activity towards other paralogs (EC50 = 22.85, 71, and 173 5.4 µM for HSP90b, GRP94 AND Trap-1, respectively). Selectively depletes cytosolic HER2 and induces its redistribution towards lysosomes and early endosomes (~20 5.4 µM) without affecting membrane associated HER2. Does not appear to be toxic towards nonmalignant cells.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number508313
Brand Family Calbiochem®
Synonyms2-Fluoro-9-(2-isopropoxyethyl)-8-(3,4,5-trimethoxybenzyl)-9H-purin-6-amine
References
ReferencesPatel, P.D., et al. 2013. Nat. Chem. Biol.9, 677.
Product Information
CAS number422508-27-8
FormOff-white powder
Hill FormulaC₂₀H₂₆FN₅O₄
Chemical formulaC₂₀H₂₆FN₅O₄
Quality LevelMQ100
Applications
Biological Information
Primary TargetHSP90a
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.08313.0001 04055977261813

Documentation

HSP90α Inhibitor, PU-29F - CAS 422508-27-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Patel, P.D., et al. 2013. Nat. Chem. Biol.9, 677.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-April-2014 JSW
Synonyms2-Fluoro-9-(2-isopropoxyethyl)-8-(3,4,5-trimethoxybenzyl)-9H-purin-6-amine
DescriptionA cell-permeable 6-amino-purine based compound that selectively binds to HSP90a (EC50 = 5.4 µM) and inhibits its activity in SKBr3 and MCF-7 breast cancer cells. Exhibits much reduced activity towards other paralogs (EC50 = 22.85, 71, and 173 5.4 µM for HSP90b, GRP94 AND Trap-1, respectively). Selectively depletes cytosolic HER2 and induces its redistribution towards lysosomes and early endosomes (~20 5.4 µM) without affecting membrane associated HER2. Does not appear to be toxic towards nonmalignant cells.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number422508-27-8
Chemical formulaC₂₀H₂₆FN₅O₄
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesPatel, P.D., et al. 2013. Nat. Chem. Biol.9, 677.