534337 HIV Inhibitor, CADA - Calbiochem

534337
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₃₁H₃₉N₃O₄S₂·HCl

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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable macrocyle cyclotriazadisulfonamide derivative compound that inhibits HIV replication (IC50 = 300 nM to 3.3 µM) and entry into cells by blocking co-translational translocation of nascent CD4 across endoplasmic reticulum membranes. Its action appears to be highly selective in reducing the expression of human CD4 and it does not affect the level of any other cell surface marker studied. Does not affect CD4 mRNA levels in cells. Shown to be effective against HIV-1 subtypes A to H, AE, and O and human herpesvirus 7 (HHV-7; IC50, 300 nM to 1.5 µM) in T-cell lines and PBMCs. Also reported to block X4 HIV-1 NL4.3 and R5 SIVmac251 laboratory strains infection in human T cells. Can act synergistically with cellulose acetate phthalate (CAP) and other anti-HIV drugs to inhibit HIV-1 and SIV infections.
      Catalogue Number534337
      Brand Family Calbiochem®
      Synonyms1-Benzyl-7-methylene-5,9-ditosyl-5,9-diaza-azoniacyclododecan-1-ium chloride, CD4 Inhibitor, CADA
      References
      ReferencesVermeire, K., et al. 2008. Curr. HIV Res. 6, 246.
      Bell, T. W., et al. 2006. J. Med. Chem. 49, 1291.
      Vermeire, K., et al. 2004. AIDS. 18, 2115.
      Vermeire, K., et al. 2002. Virology. 302, 342.
      Product Information
      FormWhite solid
      Hill FormulaC₃₁H₃₉N₃O₄S₂·HCl
      Chemical formulaC₃₁H₃₉N₃O₄S₂·HCl
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      HIV Inhibitor, CADA - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Vermeire, K., et al. 2008. Curr. HIV Res. 6, 246.
      Bell, T. W., et al. 2006. J. Med. Chem. 49, 1291.
      Vermeire, K., et al. 2004. AIDS. 18, 2115.
      Vermeire, K., et al. 2002. Virology. 302, 342.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-July-2017 JSW
      Synonyms1-Benzyl-7-methylene-5,9-ditosyl-5,9-diaza-azoniacyclododecan-1-ium chloride, CD4 Inhibitor, CADA
      DescriptionA cell-permeable macrocyle cyclotriazadisulfonamide derivative compound that inhibits HIV replication (IC50 = 300 nM to 3.3 µM) and entry into cells by blocking co-translational translocation of nascent CD4 across endoplasmic reticulum membranes. Its action appears to be highly selective in reducing the expression of human CD4 and it does not affect the level of any other cell surface marker studied. Does not affect CD4 mRNA levels in cells. Shown to be effective against HIV-1 subtypes A to H, AE, and O and human herpesvirus 7 (HHV-7; IC50, 300 nM to 1.5 µM) in T-cell lines and PBMCs. Also reported to block X4 HIV-1 NL4.3 and R5 SIVmac251 laboratory strains infection in human T cells. Can act synergistically with cellulose acetate phthalate (CAP) and other anti-HIV drugs to inhibit HIV-1 and SIV infections.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₁H₃₉N₃O₄S₂·HCl
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml). Insoluble in water.
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesVermeire, K., et al. 2008. Curr. HIV Res. 6, 246.
      Bell, T. W., et al. 2006. J. Med. Chem. 49, 1291.
      Vermeire, K., et al. 2004. AIDS. 18, 2115.
      Vermeire, K., et al. 2002. Virology. 302, 342.