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400084 HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem

400084
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Key Specifications Table

Empirical FormulaCAS #
C₂₁H₁₆ClN₃O 385786-48-1

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400084-10MG
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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2 µM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase. This compound (5 µM) is shown to significantly stabilize HIF-1α in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC50 = 0.25 µM in an oxidative stress model using cortical neurons.
      Catalogue Number400084
      Brand Family Calbiochem®
      References
      ReferencesSmirnova, N.A., et al. 2010. Chem. Biol. 4, 380.
      Product Information
      CAS number385786-48-1
      FormTan solid
      Hill FormulaC₂₁H₁₆ClN₃O
      Chemical formulaC₂₁H₁₆ClN₃O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      400084

      References

      Reference overview
      Smirnova, N.A., et al. 2010. Chem. Biol. 4, 380.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-February-2011 RFH
      DescriptionA cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2 µM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase. This compound (5 µM) is shown to significantly stabilize HIF-1α in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC50 = 0.25 µM in an oxidative stress model using cortical neurons.
      FormTan solid
      CAS number385786-48-1
      Chemical formulaC₂₁H₁₆ClN₃O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSmirnova, N.A., et al. 2010. Chem. Biol. 4, 380.