Product Information
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

HIF Inhibitor V - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Naik, R., et al. 2012. J. Med. Chem. 55, 10564.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-May-2013 JSW
Synonyms(E)-3-(3-(4-Adamantan-1-ylphenoxy)acrylamido)benzoic acid morpholinoethyl ester, Hypoxia-Inducible Factor Inhibitor V
DescriptionA cell-permeable phenoxyacrylamido compound that inhibits hypoxia-induced cellular HIF-1α accumulation in a manner similar to LW6 (Cat. No. 400083) by upregulating von Hippel-Lindau tumor suppressor gene product pVHL, but with much higher potency (IC50 = 120 nM vs 2.44 µM, respectively, against hypoxia-induced HRE reporter activity in HCT116 cells). Shown to suppress the mRNA levels of HIF-1 target genes in HCT116 cultures (VEGF, EPO, and MMP-9; effective conc. ≥2 µM) and effectively inhibit HUVEC tubule formation (effective conc. 2 to 5 µM) under hypoxia conditions.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₂H₃₈N₂O₅
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml). Use only fresh DMSO for reconstitution.
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesNaik, R., et al. 2012. J. Med. Chem. 55, 10564.

Related Products & Applications

Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Hypoxia-Inducable Factor Inhibitors