500671 HDAC Inhibitor XVII - Calbiochem

500671
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₂H₁₉NO₃

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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable N-hydroxycinnamide derivative that acts a highly potent and HDAC8-selective histone deacetylase inhibitor (IC50 = 27 nM), displaying much reduced or little potency against HDAC1/3 (IC50 = 3.0 µM), HDAC2/4/6/10/11 (IC50 >20 µM), or total HDAC activity in HeLa nuclear extract (IC50 >10 µM). Reported to preferentially inhibit the proliferation of human lung cancer cells CL1-5, H1299, and A549 (IC50 from 7 to 8 µM), while being much less toxic to normal human lung IMR-90 cells (73% inhibition at 40 µM).
      Catalogue Number500671
      Brand Family Calbiochem®
      Synonyms(E)-N-Hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamide, Histone Deacetylase Inhibitor XVII
      References
      ReferencesHuang, W. J., et al. 2012. ChemMedChem. 7, 1815.
      Product Information
      FormLight beige powder
      Hill FormulaC₂₂H₁₉NO₃
      Chemical formulaC₂₂H₁₉NO₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetHDAC8 selective
      Primary Target IC<sub>50</sub>27 nM
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      HDAC Inhibitor XVII - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Huang, W. J., et al. 2012. ChemMedChem. 7, 1815.

      Technical Info

      Title
      White Paper - The Message in the Marks: Deciphering Cancer Epigenetics (EMD)
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-July-2013 JSW
      Synonyms(E)-N-Hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamide, Histone Deacetylase Inhibitor XVII
      DescriptionA cell-permeable N-hydroxycinnamide derivative that acts a highly potent and HDAC8-selective histone deacetylase inhibitor (IC50 = 27 nM), displaying much reduced potency against HDAC1/3 (IC50 = 3.0 µM) and little or no activity toward HDAC2/4/6/10/11 (IC50 >20 µM) or total HDAC activity in HeLa nuclear extract (IC50 >10 µM). Reported to exhibit antiproliferative activity toward human lung cancer cells CL1-5, H1299, and A549 (IC50 = 7.0, 7.2, and 7.9 µM, respectively), while being much less toxic to low HDAC8-expressing CL1-1 (IC50 >10 µM) or normal human lung IMR-90 (73% inhibition at 40 µM) cells.
      FormLight beige powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₂H₁₉NO₃
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHuang, W. J., et al. 2012. ChemMedChem. 7, 1815.