368620 Group III Caspase Inhibitor I - Calbiochem

368620
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₈H₃₉FN₄O₁₀

Pricing & Availability

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368620-1MG
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      Plastic ampoule 1 mg
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      Description
      OverviewA potent, cell-permeable, and irreversible inhibitor of Group III caspases (caspase-6, -8, -9, and -10), although more effective towards caspases-6 and -8. Also inhibits caspase-1 and caspase-3. When using with purified native or recombinant enzyme, pretreatment with an esterase is required.
      Catalogue Number368620
      Brand Family Calbiochem®
      SynonymsZ-AE(OMe)VD(OMe)-FMK
      References
      ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₈H₃₉FN₄O₁₀
      Chemical formulaC₂₈H₃₉FN₄O₁₀
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcaspase-1, caspase-3, caspase-6, caspase-8, caspase-9, caspase-10
      PuritySingle spot by TLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Ala-Glu(OMe)-Val-Asp(OMe)-CH₂F*
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Group III Caspase Inhibitor I - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Group III Caspase Inhibitor I - Calbiochem Certificates of Analysis

      TitleLot Number
      368620

      References

      Reference overview
      Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-July-2008 RFH
      SynonymsZ-AE(OMe)VD(OMe)-FMK
      DescriptionA potent, cell-permeable, and irreversible inhibitor of Group III caspases (caspases-6, -8, -9, and -10), although more effective towards caspases -6 and -8. Also inhibits caspase-1 and caspase-3. When using with purified native or recombinant enzyme, pretreatment with an esterase is required.
      FormWhite solid
      Chemical formulaC₂₈H₃₉FN₄O₁₀
      Peptide SequenceZ-Ala-Glu(OMe)-Val-Asp(OMe)-CH₂F*
      PuritySingle spot by TLC
      SolubilityDMSO (20 mM)
      Storage -20°C
      Protect from moisture
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.