GF004 Granulocyte-Macrophage Colony-Stimulating Factor Protein, Recombinant human

GF004
20 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Key ApplicationsSpeciesSourcePurity
      CULT Human E.coli Greater than 98% by SDS-PAGE analysis.
      Description
      Catalogue NumberGF004
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionGranulocyte-Macrophage Colony-Stimulating Factor Protein, Recombinant human
      OvervieweGranulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a potent species-specific stimulator of bone marrow cells. GM-CSF stimulates precursor cells of granulocytes, macrophages and eosinophils. Human GM-CSF is a 14 kDa protein containing 128 amino acids residues.
      Alternate Names
      • GM-CSF
      Background InformationGM-CSF was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryocyte and eosinophil progenitors. On mature hematopoietic, monocytes/macrophages and eosinophils. GM-CSF has also been reported to have a functional role on non-hematopoitic cells. It can induce human endothelial cells to migrate and proliferate. Additionally, GM-CSF can also stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma and adenocarcinoma cell lines.
      References
      Product Information
      PresentationThe sterile filtered solution was lyophilized from 10mM Sodium Citrate, pH 3.5.
      Quality LevelMQ100
      Applications
      ApplicationThe Granulocyte Macrophage Colony Stimulating Factor protein (GM-CSF protein) is a potent species-specific stimulator of bone marrow cells.
      Key Applications
      • Cell Culture
      Application NotesFor most in vitro applications, human GM-CSF exerts its biological activity in the concentration range of 0.05 to 0.5 ng/mL. Responding cells are (partial list): Certain BM precursor cells.

      Optimal working dilutions must be determined by end user.
      Biological Information
      PurityGreater than 98% by SDS-PAGE analysis.
      SourceE.coli
      Specific ActivityHuman GM-CSF is fully biologically active when compared to standards. The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is <= 0.1 ng/mL, corresponding to a specific activity of >=1 x 10<sup>7</sup> units/mg.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.
      Gene Symbol
      • IL3
      • MGC79399
      • MCGF
      • MULTI-CSF
      • MGC79398
      • IL-3
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08700 # This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.
      SIZE: 152 amino acids; 17233 Da
      SUBUNIT: Monomer.
      SUBCELLULAR LOCATION: Secreted.
      TISSUE SPECIFICITY: Activated T-cells, mast cells, natural killer cells.
      SIMILARITY: SwissProt: P08700 ## Belongs to the IL-3 family.
      Stem Cell Type
      • Hematopoietic Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized powder, though stable at room temperature, is best stored at -20ºC. After a quick spin, reconstitute with sterile water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into other buffered solutions and stored at 2-8ºC for 1 week or -20ºC for future use. After reconstitution maintain at -20ºC in undiluted aliquots for up to six months.
      Packaging Information
      Material Size20 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Granulocyte-Macrophage Colony-Stimulating Factor Protein, Recombinant human SDS

      Title

      Safety Data Sheet (SDS) 

      Granulocyte-Macrophage Colony-Stimulating Factor Protein, Recombinant human Certificates of Analysis

      TitleLot Number
      RECOMBINANT HUMAN GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR - 23290342329034
      RECOMBINANT HUMAN GRANULOCYTE MACROPHAGE -25685432568543
      RECOMBINANT HUMAN GRANULOCYTE MACROPHAGE -26072802607280
      RECOMBINANT HUMAN GRANULOCYTE MACROPHAGE -27818652781865
      RECOMBINANT HUMAN GRANULOCYTE MACROPHAGE -28429822842982
      RECOMBINANT HUMAN GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR3168293
      RECOMBINANT HUMAN GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR2947414
      RECOMBINANT HUMAN GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR2895914
      RECOMBINANT HUMAN GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR2886908
      RECOMBINANT HUMAN GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR -26984332698433

      Data Sheet

      Title
      RECOMBINANT HUMAN GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR

      Related Products & Applications

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      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors