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508410 Glycogen Phosphorylase Inhibitor II, KB228 - Calbiochem

A mixed type inhibitor of muscle glycogen phosphorylase (Ki = 930 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: KB-228

Primary Target: Glycogen Phosphorylase
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₆H₂₂N₂O₇

Products

Catalog NumberPackaging Qty/Pack
5.08410.0001 Glass bottle 10 mg
Description
OverviewA glucopyranosyl urea compound that acts as an inhibitor of muscle glycogen phosphorylase (Ki = 930 nM). Displays a mixed type of inhibition. Enhances glucose sensitivity in chow-fed, obese, diabetic mice and increasing hepatic glucose uptake. Reduces blood glucose levels and increases hepatic glycogen content in C57/BL6J mice. Shown to increase mitochondrial oxidation in Hep2G cells under normoglycemic conditions. Enhances the expression of uncoupling proteins2 (UCP2) in HepG2 cells. This effect was less pronounced under hyperglycemic conditions.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number508410
Brand Family Calbiochem®
SynonymsKB-228
References
ReferencesNagy, L., et al. 2013. PLoS One. 8, e69420.
Product Information
FormWhite powder
Hill FormulaC₁₆H₂₂N₂O₇
Chemical formulaC₁₆H₂₂N₂O₇
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetGlycogen Phosphorylase
Primary Target K<sub>i</sub>930 nM
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number GTIN
5.08410.00014055977261943

Documentation

Glycogen Phosphorylase Inhibitor II, KB228 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Nagy, L., et al. 2013. PLoS One. 8, e69420.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-July-2014 JSW
SynonymsKB-228
DescriptionA glucopyranosyl urea compound that acts as an inhibitor of muscle glycogen phosphorylase (Ki = 930 nM). Displays a mixed type of inhibition. Enhances glucose sensitivity in chow-fed, obese, diabetic mice and increasing hepatic glucose uptake. Reduces blood glucose levels and increases hepatic glycogen content in C57/BL6J mice. Shown to increase mitochondrial oxidation in Hep2G cells under normoglycemic conditions. Enhances the expression of uncoupling proteins2 (UCP2) in HepG2 cells. This effect was less pronounced under hyperglycemic conditions.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₆H₂₂N₂O₇
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesNagy, L., et al. 2013. PLoS One. 8, e69420.