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538096 GluN2B NMDA Receptor Antagonist, 93-31 - CAS 457897-98-2 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
457897-98-2C₂₂H₃₀Cl₂N₂O₄S

Products

Catalog NumberPackaging Qty/Pack
5.38096.0001 Glass bottle 10 mg
Description
OverviewA tertiary N-alkylamine that acts as a pH dependent antagonist of GluN2B-NMDA receptors. Shown to be about 10-fold more potent in ischemic tissue (pH 6.9) than in normal healthy tissue (pH 7.6) (IC50 = 190 nM and 1.8 µM, respectively). Effectively reduces the infarct volume in damaged brain tissue in a murine model of ischemic stroke (at 10 mg/kg, ED50 ≤ 1 mg/kg) without impairing coordination or motor function. Also displays binding to hERG (IC50 = 70 nM) and alpha1-adrenergic receptor (IC50 = 4.9 µM).
Catalogue Number538096
Brand Family Calbiochem®
Synonyms(S)-N-(4-(3-(butyl(3,4-dichlorophenethyl)amino)-2-hydroxypropoxy)phenyl)methanesulfonamide
References
ReferencesYuan, H., et al. 2015. Neuron. 85, 1305.
Tahirovic, Y., et al. 2008. J. Med. Chem. 51, 5506.
Product Information
CAS number457897-98-2
FormLight yellow to yellow sticky solid
Hill FormulaC₂₂H₃₀Cl₂N₂O₄S
Chemical formulaC₂₂H₃₀Cl₂N₂O₄S
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetGluN2B NMDA Receptor
Primary Target IC<sub>50</sub>0.19 µ
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.38096.0001 04054839119521

Documentation

GluN2B NMDA Receptor Antagonist, 93-31 - CAS 457897-98-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Yuan, H., et al. 2015. Neuron. 85, 1305.
Tahirovic, Y., et al. 2008. J. Med. Chem. 51, 5506.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-July-2017 JSW
Synonyms(S)-N-(4-(3-(butyl(3,4-dichlorophenethyl)amino)-2-hydroxypropoxy)phenyl)methanesulfonamide
DescriptionA tertiary N-alkylamine that acts as a pH dependent antagonist of GluN2B-NMDA receptors. Shown to be about 10-fold more potent in ischemic tissue (pH 6.9) than in normal healthy tissue (pH 7.6) (IC50 = 190 nM and 1.8 µM, respectively). Effectively reduces the infarct volume in damaged brain tissue in a murine model of ischemic stroke (at 10 mg/kg, ED50 ≤ 1 mg/kg) without impairing coordination or motor function. Also displays binding to hERG (IC50 = 70 nM) and alpha1-adrenergic receptor (IC50 = 4.9 µM).
FormLight yellow to yellow sticky solid
Intert gas (Yes/No) Packaged under inert gas
CAS number457897-98-2
Chemical formulaC₂₂H₃₀Cl₂N₂O₄S
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesYuan, H., et al. 2015. Neuron. 85, 1305.
Tahirovic, Y., et al. 2008. J. Med. Chem. 51, 5506.