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506216 Gap Junction Enhancer, PQ7 - Calbiochem

506216
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₃H₁₉F₃N2O₃

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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable quinoline derived compound with low toxicity that enhances gap junctional activity by about 16-fold (at ~500 nM) in T47D breast cancer cells and thereby potentiates the effect of chemotherapeutic agents. Blocks T47D cell colony formation (IC50 = 100 nM) and reduce the growth of T47D xenograft tumors by 100% in Nu/Nu mice. Increases caspase-3, - 8, and -9 expression by 1.6, 2.8, and 3.8-fold, respectively to induce apoptotic cell death. Can work synergistically with cisplatin to reduce or totally eliminate tumor growth. Increases the expression of connexins 26, 32, and 43 to allow more efficient trafficking of cisplatin.
      Catalogue Number506216
      Brand Family Calbiochem®
      References
      ReferencesShishido, S.N., et al. 2013. PLos One. 8, e67174.
      Shishido, S.N., et al. 2012. PLos One. 7,e444963.
      Heiniger, B., et al. 2010. Anticancer Res. 30, 3927.
      Shi, A., et al. 2008. Bioor. Med. Chem. Lett. 18, 3364.
      Product Information
      FormTan powder
      Hill FormulaC₂₃H₁₉F₃N2O₃
      Chemical formulaC₂₃H₁₉F₃N2O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target IC<sub>50</sub>100 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Gap Junction Enhancer, PQ7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Shishido, S.N., et al. 2013. PLos One. 8, e67174.
      Shishido, S.N., et al. 2012. PLos One. 7,e444963.
      Heiniger, B., et al. 2010. Anticancer Res. 30, 3927.
      Shi, A., et al. 2008. Bioor. Med. Chem. Lett. 18, 3364.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-December-2013 JSW
      DescriptionA cell-permeable quinoline derived compound with low toxicity that enhances gap junctional activity by about 16-fold (at ~500 nM) in T47D breast cancer cells and thereby potentiates the effect of chemotherapeutic agents. Blocks T47D cell colony formation (IC50 = 100 nM) and reduce the growth of T47D xenograft tumors by 100% in Nu/Nu mice. Increases caspase-3, - 8, and -9 expression by 1.6, 2.8, and 3.8-fold, respectively to induce apoptotic cell death. Can work synergistically with cisplatin to reduce or totally eliminate tumor growth. Increases the expression of connexins 26, 32, and 43 to allow more efficient trafficking of cisplatin.
      FormTan powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₃H₁₉F₃N2O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesShishido, S.N., et al. 2013. PLos One. 8, e67174.
      Shishido, S.N., et al. 2012. PLos One. 7,e444963.
      Heiniger, B., et al. 2010. Anticancer Res. 30, 3927.
      Shi, A., et al. 2008. Bioor. Med. Chem. Lett. 18, 3364.