505296 GYKI 53655 Hydrochloride - CAS 143692-48-2 - Calbiochem

505296
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Overview

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Key Specifications Table

Empirical FormulaCAS #
C₁₉H₂₀N₄O₃•HCl 143692-48-2

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      Glass bottle 10 mg
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      Description
      OverviewA potent negative allosteric modulator selective for AMPA glutamate receptors (IC50 = 6 and 5 µM for GluA1 and GluA4, respectively) over kainate receptors (IC50 = 63 and 32 µM for GluK3 and GluK2b/GluK3 receptors. Used as neuroprotectant and anticonvulsant, and a valuable tool for the study of AMPA receptor-mediated processes in vivo.
      Catalogue Number505296
      Brand Family Calbiochem®
      SynonymsLY 300168, GYKI-53655 hydrochloride, AMPA Glutamate Receptor Antagonist, GYKI 53655 hydrochloride, 1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
      References
      ReferencesKromann, H. et al. 2002. J. Med. Chem. 45, 5745.
      Nilsen, A., et al. 2007. J. Am. Chem. Soc. 129, 4902.
      Lante, F., et al. 2011. J. Neurosci. 31, 3953.
      Argilli, E., et al. 2008. J. Neurosci. 28, 9092.
      Jackson, C., et al. 2011. J. Neurosci. 31, 7511.
      Product Information
      CAS number143692-48-2
      FormOrange solid
      Hill FormulaC₁₉H₂₀N₄O₃•HCl
      Chemical formulaC₁₉H₂₀N₄O₃•HCl
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetAMPA
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      GYKI 53655 Hydrochloride - CAS 143692-48-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Kromann, H. et al. 2002. J. Med. Chem. 45, 5745.
      Nilsen, A., et al. 2007. J. Am. Chem. Soc. 129, 4902.
      Lante, F., et al. 2011. J. Neurosci. 31, 3953.
      Argilli, E., et al. 2008. J. Neurosci. 28, 9092.
      Jackson, C., et al. 2011. J. Neurosci. 31, 7511.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-July-2013 JSW
      SynonymsLY 300168, GYKI-53655 hydrochloride, AMPA Glutamate Receptor Antagonist, GYKI 53655 hydrochloride, 1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
      DescriptionA potent negative allosteric modulator selective for AMPA glutamate receptors (IC50 = 6 and 5 µM for GluA1 and GluA4, respectively) over kainate receptors (IC50 = 63 and 32 µM for GluK3 and GluK2b/GluK3 receptors. Used as neuroprotectant and anticonvulsant, and a valuable tool for the study of AMPA receptor-mediated processes in vivo.
      FormOrange solid
      CAS number143692-48-2
      Chemical formulaC₁₉H₂₀N₄O₃•HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (100 mM)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKromann, H. et al. 2002. J. Med. Chem. 45, 5745.
      Nilsen, A., et al. 2007. J. Am. Chem. Soc. 129, 4902.
      Lante, F., et al. 2011. J. Neurosci. 31, 3953.
      Argilli, E., et al. 2008. J. Neurosci. 28, 9092.
      Jackson, C., et al. 2011. J. Neurosci. 31, 7511.