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504973 GYKI 52466 Hydrochloride - CAS 102771-26-6 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine Hydrochloride, GYKI-52,466, GYK I52466

Primary Target: AMPA
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
102771-26-6C₁₇H₁₅N₃O₂•HCl
Description
OverviewA potent negative allosteric modulator selective for AMPA glutamate receptors (IC50 = 10-20 µM) over kainate (IC50 ~ 450 µM) and NMDA (IC50 >> 50 µM) receptors. Commonly used as neuroprotectant, anticonvulsant, and skeletal muscle relaxant. Biologically viable admitted orally or systematically.
Catalogue Number504973
Brand Family Calbiochem®
Synonyms1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine Hydrochloride, GYKI-52,466, GYK I52466
References
ReferencesNayak, P., et al. 2013. Neuroscience. 232, 139.
Goulton, C., et al. 2010. Front. Neurosci. 4, 54.
Arai, C., 2001. Brain Res. 892, 396.
Wilding, J., et al. 1995. Mol. Pharmacol. 47, 582.
Donevan, D., et al. 1993. Neuron 10, 51.
Product Information
CAS number102771-26-6
FormYellow solid
Hill FormulaC₁₇H₁₅N₃O₂•HCl
Chemical formulaC₁₇H₁₅N₃O₂•HCl
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetAMPA
Primary Target IC<sub>50</sub>10 – 20 →M
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number GTIN
504973

Documentation

GYKI 52466 Hydrochloride - CAS 102771-26-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Nayak, P., et al. 2013. Neuroscience. 232, 139.
Goulton, C., et al. 2010. Front. Neurosci. 4, 54.
Arai, C., 2001. Brain Res. 892, 396.
Wilding, J., et al. 1995. Mol. Pharmacol. 47, 582.
Donevan, D., et al. 1993. Neuron 10, 51.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-July-2013 JSW
Synonyms1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine Hydrochloride, GYKI-52,466, GYK I52466
DescriptionA potent negative allosteric modulator selective for AMPA glutamate receptors (IC50 = 10-20 µM) over kainate (IC50 ~ 450 µM) and NMDA (IC50 >> 50 µM) receptors. Commonly used as neuroprotectant, anticonvulsant, and skeletal muscle relaxant. Biologically viable admitted orally or systematically.
FormYellow solid
CAS number102771-26-6
Chemical formulaC₁₇H₁₅N₃O₂•HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesNayak, P., et al. 2013. Neuroscience. 232, 139.
Goulton, C., et al. 2010. Front. Neurosci. 4, 54.
Arai, C., 2001. Brain Res. 892, 396.
Wilding, J., et al. 1995. Mol. Pharmacol. 47, 582.
Donevan, D., et al. 1993. Neuron 10, 51.