361547 GSK-3β Inhibitor VI - CAS 62673-69-2 - Calbiochem

361547
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₆H₃Br₂ClOS 62673-69-2

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361547-5MG
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      Plastic ampoule 5 mg
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      Description
      OverviewA thienyl α-chloromethyl ketone compound that acts as a cell-permeable, irreversible, and non-ATP competitive inhibitor of GSK-3β (IC50 = 1 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.
      Catalogue Number361547
      Brand Family Calbiochem®
      Synonyms2-Chloro-1-(4,5-dibromo-thiophen-2-yl)-ethanone
      References
      ReferencesConde, S., et al. 2003. J. Med. Chem. 46, 4631.
      Product Information
      CAS number62673-69-2
      ATP CompetitiveN
      FormOrange solid
      Hill FormulaC₆H₃Br₂ClOS
      Chemical formulaC₆H₃Br₂ClOS
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGsk-3β
      Primary Target IC<sub>50</sub>1 µM against Gsk-3β
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°). DMSO stock solutions are stable for up to 1 week at -20°C. For increased stability reconstitute in chloroform, aliquot, dry under a stream of inert gas, and freeze (-20°C). Reconstitute in fresh DMSO just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      GSK-3β Inhibitor VI - CAS 62673-69-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      GSK-3β Inhibitor VI - CAS 62673-69-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      361547

      References

      Reference overview
      Conde, S., et al. 2003. J. Med. Chem. 46, 4631.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      Synonyms2-Chloro-1-(4,5-dibromo-thiophen-2-yl)-ethanone
      DescriptionA cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC50 = 1 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number62673-69-2
      Chemical formulaC₆H₃Br₂ClOS
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (5 mg/ml) or Ethanol (1 mg/ml). Use fresh, anhydrous DMSO only.
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°). DMSO stock solutions are stable for up to 1 week at -20°C. For increased stability reconstitute in chloroform, aliquot, dry under a stream of inert gas, and freeze (-20°C). Reconstitute in fresh DMSO just prior to use.
      Toxicity Standard Handling
      ReferencesConde, S., et al. 2003. J. Med. Chem. 46, 4631.