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361556 GSK-3 Inhibitor IX, Control, MeBIO - CAS 710323-61-8 - Calbiochem

361556
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₇H₁₂BrN₃O₂ 710323-61-8

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361556-1MG
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      Description
      OverviewA cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as a relevant kinase inactive control (IC50 > 92 µM for Cdk1/B, > 100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC50 = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.
      Catalogue Number361556
      Brand Family Calbiochem®
      Synonyms1-Methyl-BIO
      References
      ReferencesKnockaert, M., et al. 2004. Oncogene 23, 4400.
      Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
      Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
      Product Information
      CAS number710323-61-8
      ATP CompetitiveN
      FormDark red solid
      Hill FormulaC₁₇H₁₂BrN₃O₂
      Chemical formulaC₁₇H₁₂BrN₃O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetRelevant kinase inactive control
      Primary Target IC<sub>50</sub>> 92 µM for Cdk1/B, > 100 µM for Cdk5/p25, and GSK-3α/β
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      GSK-3 Inhibitor IX, Control, MeBIO - CAS 710323-61-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      GSK-3 Inhibitor IX, Control, MeBIO - CAS 710323-61-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      361556

      References

      Reference overview
      Knockaert, M., et al. 2004. Oncogene 23, 4400.
      Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
      Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      Synonyms1-Methyl-BIO
      DescriptionA cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as an inactive control for Cdk1/cyclin B, Cdk5/p25, and GSK-3α/β (IC50 >92 µM for Cdk1/cyclin B, >100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC50 = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.
      FormDark red solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number710323-61-8
      Chemical formulaC₁₇H₁₂BrN₃O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKnockaert, M., et al. 2004. Oncogene 23, 4400.
      Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
      Meijer, L., et al. 2003. Chem. Biol. 10, 1255.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Glycogen Synthase Kinase (GSK) Inhibitors