508014 GR 127935 Hydrochloride - CAS 148642-42-6 - Calbiochem

508014
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Key Specifications Table

Empirical FormulaCAS #
C₂₉H₃₁N₅O₃·HCl 148642-42-6

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      Glass bottle 10 mg
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      Description
      OverviewA selective 5-HT1B/1D receptor antagonist. Selectivity was found to be similar for B (pki = 9.2-9.8 )and D (pki = 8.6-9.1) receptor types. GR 127935 works well in vivo and was shown to block (+)-MDMA-induced hyperactivity in rats. It alters release of serotonin in the brain, as well as reducing drug-seeking behaviour in cocaine addicted rats. In transformed rat C5 glioma cells, this inhibitor blocked 5HT with an IC50 = 97 pM.
      Catalogue Number508014
      Brand Family Calbiochem®
      Synonyms5-HT1B/1D Serotonin Receptor Antagonist, GR 127935 Hydrochloride, GR-127935 hydrochloride, GR127935 hydrochloride
      References
      ReferencesRex, A. et al. 2008. Pharmacology, Biochemistry, and Behavior. 88, 196.
      Przegalinski, E. et al. 2008. Pharmacol. Rep. 60, 798.
      Bannai, M. et al. 2007. Psychopharmacol. 93, 295.
      McCreary A. C. et al. 1999. J. Pharmacol. Exp. Ther. 290, 965.
      Pauwels, P. J. et al. 1996. J. Neurochem. 66, 65.
      Skingle, M. et al. 1996. Behav.Brain Res. 73, 157.
      Product Information
      CAS number148642-42-6
      FormOff-white solid
      Hill FormulaC₂₉H₃₁N₅O₃·HCl
      Chemical formulaC₂₉H₃₁N₅O₃·HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target5-HT1B/1D
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      GR 127935 Hydrochloride - CAS 148642-42-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Rex, A. et al. 2008. Pharmacology, Biochemistry, and Behavior. 88, 196.
      Przegalinski, E. et al. 2008. Pharmacol. Rep. 60, 798.
      Bannai, M. et al. 2007. Psychopharmacol. 93, 295.
      McCreary A. C. et al. 1999. J. Pharmacol. Exp. Ther. 290, 965.
      Pauwels, P. J. et al. 1996. J. Neurochem. 66, 65.
      Skingle, M. et al. 1996. Behav.Brain Res. 73, 157.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-September-2013 JSW
      Synonyms5-HT1B/1D Serotonin Receptor Antagonist, GR 127935 Hydrochloride, GR-127935 hydrochloride, GR127935 hydrochloride
      DescriptionA selective 5-HT1B/1D receptor antagonist. Selectivity was found to be similar for B (pki = 9.2-9.8 )and D (pki = 8.6-9.1) receptor types. GR 127935 works well in vivo and was shown to block (+)-MDMA-induced hyperactivity in rats. It alters release of serotonin in the brain, as well as reducing drug-seeking behaviour in cocaine addicted rats. In transformed rat C5 glioma cells, this inhibitor blocked 5HT with an IC50 = 97 pM.
      FormOff-white solid
      CAS number148642-42-6
      Chemical formulaC₂₉H₃₁N₅O₃·HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesRex, A. et al. 2008. Pharmacology, Biochemistry, and Behavior. 88, 196.
      Przegalinski, E. et al. 2008. Pharmacol. Rep. 60, 798.
      Bannai, M. et al. 2007. Psychopharmacol. 93, 295.
      McCreary A. C. et al. 1999. J. Pharmacol. Exp. Ther. 290, 965.
      Pauwels, P. J. et al. 1996. J. Neurochem. 66, 65.
      Skingle, M. et al. 1996. Behav.Brain Res. 73, 157.