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371830 GPR40 Antagonist, GW1100 - CAS 306974-70-9 - Calbiochem

371830
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Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₇H₂₅FN₄O₄S 306974-70-9

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371830-10MG
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      Description
      OverviewA cell-permeable pyrimidinylmethyl-pyrimidinone compound that acts as potent, reversible and non-competitive GPR40 antagonist. Selectively blocks GPR40-mediated intracellular Ca2+ release stimulated by GPR40 Agonist GW9508 (Cat. No. 371706) and linoleic acid (pIC50 of 5.99 in GPR40 expressing HEK293 cells) with no effect on GPR120-mediated activation. Shown to significantly reverse glucose-induced insulin secretion potentiated by GW9508 and only partially reduce linoleic acid effect in MIN6 cells.
      Catalogue Number371830
      Brand Family Calbiochem®
      Synonyms1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone, SB376752
      References
      ReferencesStoddart, L.A., et al. 2007. Mol. Pharmacol. 71, 994.
      Briscoe, C.P., et al. 2006. Br. J. Pharmacol. 148, 619.
      Product Information
      CAS number306974-70-9
      FormWhite powder
      Hill FormulaC₂₇H₂₅FN₄O₄S
      Chemical formulaC₂₇H₂₅FN₄O₄S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      GPR40 Antagonist, GW1100 - CAS 306974-70-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      GPR40 Antagonist, GW1100 - CAS 306974-70-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      371830

      References

      Reference overview
      Stoddart, L.A., et al. 2007. Mol. Pharmacol. 71, 994.
      Briscoe, C.P., et al. 2006. Br. J. Pharmacol. 148, 619.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-August-2012 JSW
      Synonyms1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone, SB376752
      DescriptionA cell-permeable pyrimidinylmethyl-pyrimidinone compound that acts as potent, reversible and non-competitive GPR40 antagonist. Selectively blocks GPR40-mediated intracellular Ca2+ release stimulated by GPR40 Agonist GW9508 (Cat. No. 371706) and linoleic acid (pIC50 of 5.99 in GPR40 expressing HEK293 cells) with no effect on GPR120-mediated activation. Shown to significantly reverse glucose-induced insulin secretion potentiated by GW9508 and only partially reduce linoleic acid effect in MIN6 cells.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number306974-70-9
      Chemical formulaC₂₇H₂₅FN₄O₄S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesStoddart, L.A., et al. 2007. Mol. Pharmacol. 71, 994.
      Briscoe, C.P., et al. 2006. Br. J. Pharmacol. 148, 619.