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505732 GBR 12909 Dihydrochloride - CAS 67469-78-7 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
67469-78-7C₂₈H₃₂F₂N₂O•2HCl

Products

Catalog NumberPackaging Qty/Pack
5.05732.0001 Glass bottle 10 mg
Description
OverviewA potent inhibitor of dopamine active transporter (DAT, Ki = 1 nM, IC50 = 40 and 51 nM) with >100 fold selectivity over noradrenalin and 5-HT re-uptake transporter. Shown to produce behavioral profile in mice for bipolar mania disease model and ADHD disease models.
Catalogue Number505732
Brand Family Calbiochem®
Synonyms1-(2-Bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine Hydrochloride, Dopamine Active Transporter Inhibitor, GBR 12909, DAT Inhibitor, GBR 12909, GBR12909
References
ReferencesYoung, J. et al. 2010. Psychopharm. 208, 443.
Hewitt, K., et al. 2009. Neuropharm. 57, 678.
Prisinzano, T. et al. 2002. J. Med. Chem. 45, 4371.
Andersen, P., et al. 1989. Eur. J. Pharmacol. 166, 493.
Heikkila, R., et al. 1984. Eur. J. Pharmacol. 103, 142.
Product Information
CAS number67469-78-7
FormWhite to off-white solid
Hill FormulaC₂₈H₃₂F₂N₂O•2HCl
Chemical formulaC₂₈H₃₂F₂N₂O•2HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetDAT
Primary Target K<sub>i</sub>1 nM
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number GTIN
5.05732.00014055977243444

Documentation

GBR 12909 Dihydrochloride - CAS 67469-78-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Young, J. et al. 2010. Psychopharm. 208, 443.
Hewitt, K., et al. 2009. Neuropharm. 57, 678.
Prisinzano, T. et al. 2002. J. Med. Chem. 45, 4371.
Andersen, P., et al. 1989. Eur. J. Pharmacol. 166, 493.
Heikkila, R., et al. 1984. Eur. J. Pharmacol. 103, 142.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-April-2018 JSW
Synonyms1-(2-Bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine Hydrochloride, Dopamine Active Transporter Inhibitor, GBR 12909, DAT Inhibitor, GBR 12909, GBR12909
DescriptionA potent inhibitor of dopamine active transporter (DAT, Ki = 1 nM, IC50 = 40 and 51 nM) with >100 fold selectivity over noradrenalin and 5-HT re-uptake transporter. Shown to produce behavioral profile in mice for bipolar mania disease model and ADHD disease models.
FormWhite to off-white solid
CAS number67469-78-7
Chemical formulaC₂₈H₃₂F₂N₂O•2HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mM). Slight warming is required for complete solubilization.
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesYoung, J. et al. 2010. Psychopharm. 208, 443.
Hewitt, K., et al. 2009. Neuropharm. 57, 678.
Prisinzano, T. et al. 2002. J. Med. Chem. 45, 4371.
Andersen, P., et al. 1989. Eur. J. Pharmacol. 166, 493.
Heikkila, R., et al. 1984. Eur. J. Pharmacol. 103, 142.