505732 GBR 12909 Dihydrochloride - CAS 67469-78-7 - Calbiochem

505732
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Key Specifications Table

Empirical FormulaCAS #
C₂₈H₃₂F₂N₂O•2HCl 67469-78-7

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      Glass bottle 10 mg
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      Description
      OverviewA potent inhibitor of dopamine active transporter (DAT, Ki = 1 nM, IC50 = 40 and 51 nM) with >100 fold selectivity over noradrenalin and 5-HT re-uptake transporter. Shown to produce behavioral profile in mice for bipolar mania disease model and ADHD disease models.
      Catalogue Number505732
      Brand Family Calbiochem®
      Synonyms1-(2-Bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine Hydrochloride, Dopamine Active Transporter Inhibitor, GBR 12909, DAT Inhibitor, GBR 12909, GBR12909
      References
      ReferencesYoung, J. et al. 2010. Psychopharm. 208, 443.
      Hewitt, K., et al. 2009. Neuropharm. 57, 678.
      Prisinzano, T. et al. 2002. J. Med. Chem. 45, 4371.
      Andersen, P., et al. 1989. Eur. J. Pharmacol. 166, 493.
      Heikkila, R., et al. 1984. Eur. J. Pharmacol. 103, 142.
      Product Information
      CAS number67469-78-7
      FormWhite to off-white solid
      Hill FormulaC₂₈H₃₂F₂N₂O•2HCl
      Chemical formulaC₂₈H₃₂F₂N₂O•2HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetDAT
      Primary Target K<sub>i</sub>1 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      GBR 12909 Dihydrochloride - CAS 67469-78-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Young, J. et al. 2010. Psychopharm. 208, 443.
      Hewitt, K., et al. 2009. Neuropharm. 57, 678.
      Prisinzano, T. et al. 2002. J. Med. Chem. 45, 4371.
      Andersen, P., et al. 1989. Eur. J. Pharmacol. 166, 493.
      Heikkila, R., et al. 1984. Eur. J. Pharmacol. 103, 142.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-April-2018 JSW
      Synonyms1-(2-Bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine Hydrochloride, Dopamine Active Transporter Inhibitor, GBR 12909, DAT Inhibitor, GBR 12909, GBR12909
      DescriptionA potent inhibitor of dopamine active transporter (DAT, Ki = 1 nM, IC50 = 40 and 51 nM) with >100 fold selectivity over noradrenalin and 5-HT re-uptake transporter. Shown to produce behavioral profile in mice for bipolar mania disease model and ADHD disease models.
      FormWhite to off-white solid
      CAS number67469-78-7
      Chemical formulaC₂₈H₃₂F₂N₂O•2HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mM). Slight warming is required for complete solubilization.
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesYoung, J. et al. 2010. Psychopharm. 208, 443.
      Hewitt, K., et al. 2009. Neuropharm. 57, 678.
      Prisinzano, T. et al. 2002. J. Med. Chem. 45, 4371.
      Andersen, P., et al. 1989. Eur. J. Pharmacol. 166, 493.
      Heikkila, R., et al. 1984. Eur. J. Pharmacol. 103, 142.