C87727Millipore offers specific and validated Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) antibodies. See below for products for GAPDH, based on the expertise of Upstate & Chemicon.
Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is an ubiquitous glycolytic enzyme present in reasonably high levels in almost all tissues. As a 'house-keeping' enzyme, it catalyzes the synthesis of 1,3-biphosphoglycerate, a "high energy" intermediate used for the synthesis of ATP. It is also involved in the initial stages of apoptosis or oxidative stress response where GAPDH is translocated to the nucleus. GAPDH has also been found to bind specifically to proteins implicated in the pathogenesis of a variety of neurodegenerative disorders including the beta-amyloid precursor protein and the huntingtin. GAPDH has also been identified as a potential target for nitric oxide (NO)-mediated cellular toxicity.