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344850 Fumonisin B₁, Fusarium moniliforme - CAS 116355-83-0 - Calbiochem

A cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase; IC₅₀ = 100 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: FB₁

Primary Target: ceramide synthase
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
116355-83-0C₃₄H₅₉NO₁₅

Products

Catalog NumberPackaging Qty/Pack
344850-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase; IC50 = 100 nM). Preferentially inhibits sphingomyelin biosynthesis in neuronal cells. Exhibits carcinogenic properties.
Catalogue Number344850
Brand Family Calbiochem®
SynonymsFB₁
References
ReferencesWu, W.I., et al. 1995. J. Biol. Chem. 270, 13171.
Riley, R.T., et al. 1994. J. Nutr. 124, 594.
Wolf, G. 1994. Nutr. Rev. 52, 246.
Merrill, A.H. Jr., et al. 1993. Adv. Lipid Res. 26, 215.
Merrill, Jr., A.H., et al. 1993. J. Biol. Chem. 268, 27299.
Voss, K.A., et al. 1993. Nat. Toxins 1, 222.
Wang, E., et al. 1991. J. Biol. Chem. 266, 14486.
Harrison, L.R., et al. 1990. J. Vet. Diag. Invest. 2, 217.
Product Information
CAS number116355-83-0
ATP CompetitiveN
FormWhite to beige powder
Hill FormulaC₃₄H₅₉NO₁₅
Chemical formulaC₃₄H₅₉NO₁₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetceramide synthase
Primary Target IC<sub>50</sub>100 nM against sphingosine N-acyltransferase (ceramide synthase)
Purity≥95% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSTZ8350000
Safety Information
R PhraseR: 40

Limited evidence of a carcinogenic effect.
S PhraseS: 22-26-36/37/39

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number GTIN
344850-1MG4055977214871

Documentation

Fumonisin B₁, Fusarium moniliforme - CAS 116355-83-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Fumonisin B₁, Fusarium moniliforme - CAS 116355-83-0 - Calbiochem Certificates of Analysis

TitleLot Number
344850

References

Reference overview
Wu, W.I., et al. 1995. J. Biol. Chem. 270, 13171.
Riley, R.T., et al. 1994. J. Nutr. 124, 594.
Wolf, G. 1994. Nutr. Rev. 52, 246.
Merrill, A.H. Jr., et al. 1993. Adv. Lipid Res. 26, 215.
Merrill, Jr., A.H., et al. 1993. J. Biol. Chem. 268, 27299.
Voss, K.A., et al. 1993. Nat. Toxins 1, 222.
Wang, E., et al. 1991. J. Biol. Chem. 266, 14486.
Harrison, L.R., et al. 1990. J. Vet. Diag. Invest. 2, 217.

Citations

Title
  • Rita Fishelevich, et al. (2006) Ceramide-Dependent Regulation of Human Epidermal Keratinocyte CD1d Expression during Terminal Differentiation. Journal of Immunology 176, 2590-2599.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision30-January-2017 JSW
    SynonymsFB₁
    DescriptionFumonisin B1 is a neurotoxin and a phytotoxin. A cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase) (IC50 = 100 nM). Cellular effects also appear to be induced by micromolar levels of FB1. Because it inhibits ceramide synthase activity, it elevates cellular levels of sphingoid bases, including sphinganine, resulting in overall inhibition of sphingolipid biosynthesis. Preferentially inhibits sphingomyelin biosynthesis in neuronal cells. Has carcinogenic properties.
    FormWhite to beige powder
    CAS number116355-83-0
    RTECSTZ8350000
    Chemical formulaC₃₄H₅₉NO₁₅
    Structure formulaStructure formula
    Purity≥95% by TLC
    SolubilityMethanol (5 mg/ml)
    Storage +2°C to +8°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
    Toxicity Carcinogenic / Teratogenic
    Merck USA index14, 4289
    ReferencesWu, W.I., et al. 1995. J. Biol. Chem. 270, 13171.
    Riley, R.T., et al. 1994. J. Nutr. 124, 594.
    Wolf, G. 1994. Nutr. Rev. 52, 246.
    Merrill, A.H. Jr., et al. 1993. Adv. Lipid Res. 26, 215.
    Merrill, Jr., A.H., et al. 1993. J. Biol. Chem. 268, 27299.
    Voss, K.A., et al. 1993. Nat. Toxins 1, 222.
    Wang, E., et al. 1991. J. Biol. Chem. 266, 14486.
    Harrison, L.R., et al. 1990. J. Vet. Diag. Invest. 2, 217.
    Citation
  • Rita Fishelevich, et al. (2006) Ceramide-Dependent Regulation of Human Epidermal Keratinocyte CD1d Expression during Terminal Differentiation. Journal of Immunology 176, 2590-2599.
    		•