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505991 Flumazenil - CAS 78755-81-4 - Calbiochem

505991
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Key Specifications Table

Empirical FormulaCAS #
C₁₅H₁₄FN₃O₃ 78755-81-4

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      Glass bottle 10 mg
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      Description
      OverviewA competitive blocker of benzodiazepine activation of inhibitory GABAergic synpases (ID50 = 200 µg/kg/i.p). Binds to the benzodiazepine site of GABAA receptors. Enhances GABAA-receptor mediated currents and antagonizes the enhancing effects of benzodiapine agonist flurazepam. Exhibits fast association and dissociation from the benzodiazepine binding site. Permeates the blood brain barrier, however, the level of uptake may depend on efflux effects of p-glycogprotein transporter.
      Catalogue Number505991
      Brand Family Calbiochem®
      SynonymsGABAA Receptor Antagonist, Flumazenil, Ro 15-1788
      References
      ReferencesFroklage, F.E., et al. 2012. EJNMMI Research. 2, 12.
      Li, J., et al. 2006. Neuropharmacol. 51, 168.
      Weiss, M., et al. 2002. Neurochem. Res. 27, 1605.
      Atack, J., et al. 1999. Neuropsychopharmacol. 20, 255.
      Votey, S.R., et al. 1991. Ann. Emerg. Med. 20, 181.
      Product Information
      CAS number78755-81-4
      FormWhite solid
      Hill FormulaC₁₅H₁₄FN₃O₃
      Chemical formulaC₁₅H₁₄FN₃O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGABAA
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Flumazenil - CAS 78755-81-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Froklage, F.E., et al. 2012. EJNMMI Research. 2, 12.
      Li, J., et al. 2006. Neuropharmacol. 51, 168.
      Weiss, M., et al. 2002. Neurochem. Res. 27, 1605.
      Atack, J., et al. 1999. Neuropsychopharmacol. 20, 255.
      Votey, S.R., et al. 1991. Ann. Emerg. Med. 20, 181.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2013 JSW
      SynonymsGABAA Receptor Antagonist, Flumazenil, Ro 15-1788
      DescriptionA competitive blocker of benzodiazepine activation of inhibitory GABAergic synpases (ID50 = 200 mg/kg/i.p). Binds to the benzodiazepine site of GABAA receptors. Enhances GABAA-receptor mediated currents and antagonizes the enhancing effects of benzodiapine agonist flurazepam. Exhibits fast association and dissociation from the benzodiazepine binding site. Permeates the blood brain barrier, however, the level of uptake may depend on efflux effects of p-glycogprotein transporter.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number78755-81-4
      Chemical formulaC₁₅H₁₄FN₃O₃
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (25 mM). Slight warming is required for complete solubilization.
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesFroklage, F.E., et al. 2012. EJNMMI Research. 2, 12.
      Li, J., et al. 2006. Neuropharmacol. 51, 168.
      Weiss, M., et al. 2002. Neurochem. Res. 27, 1605.
      Atack, J., et al. 1999. Neuropsychopharmacol. 20, 255.
      Votey, S.R., et al. 1991. Ann. Emerg. Med. 20, 181.