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341251 Fascaplysin, Synthetic - CAS 114719-57-2 - Calbiochem

A cell-permeable red pigment, originally isolated from marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/D1 (IC₅₀ = 0.35 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: CDK4/D1
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341251
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
114719-57-2C₁₈H₁₁ClN₂O

Products

Catalog NumberPackaging Qty/Pack
341251-1MG Alu drum 1 mg
Description
OverviewA cell-permeable red pigment, originally isolated from marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/D1 (IC50 = 0.35 µM). It inhibits Cdk6/D1 with much lower potency (IC50 = 3.4 µM) and has been shown not to affect the activities of several other Cdk’s (IC50 > 20 µM) and tyrosine kinases (IC50 > 10 µM). Part of its biological effects may also be attributed to its ability to intercalate into DNA. Has also been shown to display anti-microbial activity.
Catalogue Number341251
Brand Family Calbiochem®
References
ReferencesHormann, A., et al. 2001. Bioorg. Med. Chem. 9, 917.
Kirsch, G., et al. 2000. J. Nat. Prod. 63, 825.
Soni, R., et al. 2000. Biochem. Biophys. Res. Commun. 275, 877.
Product Information
CAS number114719-57-2
ATP CompetitiveY
FormBrown solid
Hill FormulaC₁₈H₁₁ClN₂O
Chemical formulaC₁₈H₁₁ClN₂O
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCDK4/D1
Primary Target IC<sub>50</sub>0.35 µM against Cdk4/D1
Purity≥98% by NMR
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number GTIN
341251-1MG4055977215519

Documentation

Fascaplysin, Synthetic - CAS 114719-57-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Fascaplysin, Synthetic - CAS 114719-57-2 - Calbiochem Certificates of Analysis

TitleLot Number
341251

References

Reference overview
Hormann, A., et al. 2001. Bioorg. Med. Chem. 9, 917.
Kirsch, G., et al. 2000. J. Nat. Prod. 63, 825.
Soni, R., et al. 2000. Biochem. Biophys. Res. Commun. 275, 877.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-April-2011 RFH
DescriptionA cell-permeable red pigment, originally isolated from a species of marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/cyclin D1 (IC50 = 350 nM). Reported to inhibit Cdk6/cyclin D1 with much lower potency (IC50 = 3.4 µM). Exhibits little to no effect on the activities of several other Cdk's (IC50 >20 µM) and tyrosine kinases (IC50 >10 µM). Biological effects are attributed, in part, to its ability to intercalate into DNA. Also displays anti-microbial activity.
FormBrown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number114719-57-2
Chemical formulaC₁₈H₁₁ClN₂O
Structure formulaStructure formula
Purity≥98% by NMR
SolubilityDMSO (10 mg/ml) or Methanol (1 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Toxic
ReferencesHormann, A., et al. 2001. Bioorg. Med. Chem. 9, 917.
Kirsch, G., et al. 2000. J. Nat. Prod. 63, 825.
Soni, R., et al. 2000. Biochem. Biophys. Res. Commun. 275, 877.