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344597 FTY720

344597
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₉H₃₃NO₂ • HCl 162359-56-0

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344597-10MG
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      Glass bottle 10 mg
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      Description
      Overview

      A cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPγS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
      Catalogue Number344597
      Brand Family Calbiochem®
      Synonyms2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol, HCl
      References
      ReferencesBrinkmann, V and Lynch, K. R., 2002. Curr. Opin. Immunol. 14, 569.
      Brinkmann, V., et al. 2002. J. Biol. Chem. 277, 21453.
      Mandala, S., et al. 2002. Science 296, 346.
      Chiba, K., et al. 1998. J. Immunol. 160, 5037.
      Adachi, K., et al. 1995. Bioorg. Med. Chem. Lett. 5, 583.
      Product Information
      CAS number162359-56-0
      FormSolid
      Hill FormulaC₁₉H₃₃NO₂ • HCl
      Chemical formulaC₁₉H₃₃NO₂ • HCl
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      FTY720 Certificates of Analysis

      TitleLot Number
      344597

      References

      Reference overview
      Brinkmann, V and Lynch, K. R., 2002. Curr. Opin. Immunol. 14, 569.
      Brinkmann, V., et al. 2002. J. Biol. Chem. 277, 21453.
      Mandala, S., et al. 2002. Science 296, 346.
      Chiba, K., et al. 1998. J. Immunol. 160, 5037.
      Adachi, K., et al. 1995. Bioorg. Med. Chem. Lett. 5, 583.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-June-2008 RFH
      Synonyms2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol, HCl
      DescriptionA cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPγS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
      FormSolid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number162359-56-0
      Chemical formulaC₁₉H₃₃NO₂ • HCl
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (20 mg/ml) or Ethanol (20 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBrinkmann, V and Lynch, K. R., 2002. Curr. Opin. Immunol. 14, 569.
      Brinkmann, V., et al. 2002. J. Biol. Chem. 277, 21453.
      Mandala, S., et al. 2002. Science 296, 346.
      Chiba, K., et al. 1998. J. Immunol. 160, 5037.
      Adachi, K., et al. 1995. Bioorg. Med. Chem. Lett. 5, 583.