341589 FGF, Acidic, Mouse, Recombinant

341589
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Overview

Replacement Information

Key Specifications Table

Purity
≥95% SDS-PAGE

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
341589-25UG
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      Glass bottle 25 μg
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      Description
      OverviewRecombinant, mouse fibroblast growth factor (FGF) acidic, consisting of amino acids 16-155 and expressed in E. coli, with an N-terminal Met. FGF acidic stimulates proliferation of all cells of mesodermal origin and many cells of ectodermal, neuroectodermal, and endodermal origin. Intracellular FGF acidic inhibits p53 activity and proapoptotic signaling, thereby enabling it to function as a survival factor.
      Catalogue Number341589
      Brand Family Calbiochem®
      SynonymsHBGF-1
      References
      ReferencesGuerrini, M., et al. 2007. Curr. Pharm. Des. 13, 2045.
      Nilsen, T., et al. 2007. J. Biol. Chem. 282, 26245.
      Rajalingam, D., et al. 2007. Biochemistry 46, 9225.
      Wesche, J., et al. 2006. J. Biol. Chem. 281, 11405.
      Bouleau, S., et al. 2005. Oncogene 24, 7839.
      Mohammadi, M., et al. 2005. Cytokine Growth Factor Rev. 16, 107.
      Presta, M., et al. 2005. Cytokine Growth Factor Rev. 16, 159.
      Robinson, C.J., et al. 2005. J. Biol. Chem. 280, 42274.
      Wesche, J., et al. 2005. Biochemistry 44, 6071.
      Wiedlocha, A., et al. 2005. Mol. Biol. Cell 16, 794.
      Wiedlocha, A. and V. Sorensen. 2004. Curr. Top. Microbiol. Immunol. 286, 45.
      Allen, B.L. and A.C. Rapraeger. 2003. J. Cell Biol. 163, 637.
      Galzie, Z., et al. 1997. Biochem. Cell Biol. 75, 669.
      Madiai, F., et al. 1996. Gene 179, 231.
      Imamura, T., et al. 1990. Science 249, 1567.
      Product Information
      FormSolid
      FormulationLyophilized from 0.2 µm sterile-filtered solution in MOPS, Na₂SO₄, EDTA, DTT, BSA.
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityED₅₀ = 0.05-0.25 ng/ml, in the presence of 10 µg/ml heparin, as measured in a cell proliferation assay using NR6R-3T3 mouse fibroblasts.
      Purity≥95% SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: <1.0 EU/µg protein
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      FGF, Acidic, Mouse, Recombinant SDS

      Title

      Safety Data Sheet (SDS) 

      FGF, Acidic, Mouse, Recombinant Certificates of Analysis

      TitleLot Number
      341589

      References

      Reference overview
      Guerrini, M., et al. 2007. Curr. Pharm. Des. 13, 2045.
      Nilsen, T., et al. 2007. J. Biol. Chem. 282, 26245.
      Rajalingam, D., et al. 2007. Biochemistry 46, 9225.
      Wesche, J., et al. 2006. J. Biol. Chem. 281, 11405.
      Bouleau, S., et al. 2005. Oncogene 24, 7839.
      Mohammadi, M., et al. 2005. Cytokine Growth Factor Rev. 16, 107.
      Presta, M., et al. 2005. Cytokine Growth Factor Rev. 16, 159.
      Robinson, C.J., et al. 2005. J. Biol. Chem. 280, 42274.
      Wesche, J., et al. 2005. Biochemistry 44, 6071.
      Wiedlocha, A., et al. 2005. Mol. Biol. Cell 16, 794.
      Wiedlocha, A. and V. Sorensen. 2004. Curr. Top. Microbiol. Immunol. 286, 45.
      Allen, B.L. and A.C. Rapraeger. 2003. J. Cell Biol. 163, 637.
      Galzie, Z., et al. 1997. Biochem. Cell Biol. 75, 669.
      Madiai, F., et al. 1996. Gene 179, 231.
      Imamura, T., et al. 1990. Science 249, 1567.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-Sepmtember-2011 RFH
      SynonymsHBGF-1
      DescriptionRecombinant, mouse fibroblast growth factor (FGF) acidic, consisting of amino acids 16-155 and expressed in E. coli, with an N-terminal Met. FGF acidic stimulates proliferation of all cells of mesodermal origin and many cells of ectodermal, neuroectodermal, and endodermal origin. Intracellular FGF acidic inhibits p53 activity and proapoptotic signaling, thereby enabling it to function as a survival factor.
      FormSolid
      FormulationLyophilized from 0.2 µm sterile-filtered solution in MOPS, Na₂SO₄, EDTA, DTT, BSA.
      Purity≥95% SDS-PAGE
      ContaminantsEndotoxin: <1.0 EU/µg protein
      Biological activityED₅₀ = 0.05-0.25 ng/ml, in the presence of 10 µg/ml heparin, as measured in a cell proliferation assay using NR6R-3T3 mouse fibroblasts.
      SolubilityReconstitute to 100 µg/ml in sterile PBS containing at least 0.1% human or bovine serum albumin.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesGuerrini, M., et al. 2007. Curr. Pharm. Des. 13, 2045.
      Nilsen, T., et al. 2007. J. Biol. Chem. 282, 26245.
      Rajalingam, D., et al. 2007. Biochemistry 46, 9225.
      Wesche, J., et al. 2006. J. Biol. Chem. 281, 11405.
      Bouleau, S., et al. 2005. Oncogene 24, 7839.
      Mohammadi, M., et al. 2005. Cytokine Growth Factor Rev. 16, 107.
      Presta, M., et al. 2005. Cytokine Growth Factor Rev. 16, 159.
      Robinson, C.J., et al. 2005. J. Biol. Chem. 280, 42274.
      Wesche, J., et al. 2005. Biochemistry 44, 6071.
      Wiedlocha, A., et al. 2005. Mol. Biol. Cell 16, 794.
      Wiedlocha, A. and V. Sorensen. 2004. Curr. Top. Microbiol. Immunol. 286, 45.
      Allen, B.L. and A.C. Rapraeger. 2003. J. Cell Biol. 163, 637.
      Galzie, Z., et al. 1997. Biochem. Cell Biol. 75, 669.
      Madiai, F., et al. 1996. Gene 179, 231.
      Imamura, T., et al. 1990. Science 249, 1567.