341208 Exoenzyme C3, Clostridium botulinum

341208
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Overview

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341208-25UG
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      Glass bottle 25 μg
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      341208-50UG
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          Plastic ampoule 50 μg
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          Description
          OverviewCatalyzes the hydrolysis of NAD and, in the presence of Rho, catalyzes the ADP-ribosylation of Asn41 in Rho. Inhibits the progression of the cell cycle from G1 to S phase.
          Catalogue Number341208
          Brand Family Calbiochem®
          References
          ReferencesUdagawa, T., and McIntyre, B.W. 1996. J. Biol. Chem. 271, 12542.
          Yamamoto, M., et al. 1994. J. Dermatol. Sci. 8, 103.
          Yamamoto, M., et al. 1993. Oncogene 8, 1449.
          Popoff, A., et al. 1991. Infect. Immun. 59, 3673.
          Morii, N., et al. 1988. J. Biol. Chem. 263, 12420.
          Hartree, E.F. 1972. Anal. Biochem. 48, 422.
          Weber, K., and Osborn, M. 1969. J. Biol. Chem. 244, 4406.
          Product Information
          CAS number58319-92-9
          FormSolid
          FormulationLyophilized from 20 mM Tris, 50 mM NaCl, 0.5% sucrose, 0.1% dextran, pH 7.5
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥90% by SDS-PAGE
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 37

          Irritating to respiratory system.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 months at -70°C.
          Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Exoenzyme C3, Clostridium botulinum Certificates of Analysis

          TitleLot Number
          341208

          References

          Reference overview
          Udagawa, T., and McIntyre, B.W. 1996. J. Biol. Chem. 271, 12542.
          Yamamoto, M., et al. 1994. J. Dermatol. Sci. 8, 103.
          Yamamoto, M., et al. 1993. Oncogene 8, 1449.
          Popoff, A., et al. 1991. Infect. Immun. 59, 3673.
          Morii, N., et al. 1988. J. Biol. Chem. 263, 12420.
          Hartree, E.F. 1972. Anal. Biochem. 48, 422.
          Weber, K., and Osborn, M. 1969. J. Biol. Chem. 244, 4406.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-June-2016 RB
          DescriptionCatalyzes the hydrolysis of NAD. Can be used as a reagent for the detection of Rho proteins. Predominantly catalyzes the ADP ribosylation of the Asn41 amino acid residue in Rho. Treatment of cultured cells with exoenzyme C3 has been shown to induce ADP-ribosylation of RhoA protein and to reduce cell growth rate and saturation density. Its growth inhibitory effects appear to result from blockage at the G1 to S phase transition, causing the accumulation of cells in the G1 phase.
          FormSolid
          FormulationLyophilized from 20 mM Tris, 50 mM NaCl, 0.5% sucrose, 0.1% dextran, pH 7.5
          CAS number58319-92-9
          Purity≥90% by SDS-PAGE
          SolubilityReconstitute with sterile distilled H₂O
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 months at -70°C.
          Toxicity Irritant
          ReferencesUdagawa, T., and McIntyre, B.W. 1996. J. Biol. Chem. 271, 12542.
          Yamamoto, M., et al. 1994. J. Dermatol. Sci. 8, 103.
          Yamamoto, M., et al. 1993. Oncogene 8, 1449.
          Popoff, A., et al. 1991. Infect. Immun. 59, 3673.
          Morii, N., et al. 1988. J. Biol. Chem. 263, 12420.
          Hartree, E.F. 1972. Anal. Biochem. 48, 422.
          Weber, K., and Osborn, M. 1969. J. Biol. Chem. 244, 4406.