341205 Etoposide - CAS 33419-42-0 - Calbiochem

341205
View Pricing & Availability

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₉H₃₂O₁₃ 33419-42-0

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
341205-25MG
Retrieving availability...
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Plastic ampoule 25 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity needs to be mulitiple of
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      Description
      OverviewA cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC50 = 59.2 µM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells.
      Catalogue Number341205
      Brand Family Calbiochem®
      SynonymsVP-16
      References
      ReferencesDe Lange, A.M., et al. 1995. J. Virol. 69, 2082.
      Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
      Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
      Terada, T., et al. 1993. J. Med. Chem. 36, 1689.
      Wazniak, A.J., et al. 1991. J. Clin. Oncol. 9, 70.
      Einhorn, L.H., et al. 1988. J. Clin. Oncol. 6, 451.
      Issel, B.F. 1982. Cancer Chemother. Pharmacol. 7, 73.
      Product Information
      CAS number33419-42-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₉H₃₂O₁₃
      Chemical formulaC₂₉H₃₂O₁₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationEtoposide, CAS 33419-42-0, is cell-permeable inhibitor of topoisomerase II inhibitor (IC50 = 59.2 µM). Displays anti-tumor activity.
      Biological Information
      Primary Targettopoisomerase 2
      Primary Target IC<sub>50</sub>59.2 µM inhibiting topoisomerase II
      Purity>97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSKC0190000
      Safety Information
      R PhraseR: 22-45

      Harmful if swallowed.
      May cause cancer.
      S PhraseS: 26-36/37/39-45-53

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Avoid exposure - obtain special instructions before use.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Etoposide - CAS 33419-42-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Etoposide - CAS 33419-42-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      341205

      References

      Reference overview
      De Lange, A.M., et al. 1995. J. Virol. 69, 2082.
      Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
      Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
      Terada, T., et al. 1993. J. Med. Chem. 36, 1689.
      Wazniak, A.J., et al. 1991. J. Clin. Oncol. 9, 70.
      Einhorn, L.H., et al. 1988. J. Clin. Oncol. 6, 451.
      Issel, B.F. 1982. Cancer Chemother. Pharmacol. 7, 73.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-May-2008 RFH
      SynonymsVP-16
      DescriptionA cell-permeable, topoisomerase II inhibitor (IC50 = 59.2 µM). A derivative of podophyllotoxin (Cat. No. 540040) that has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells.
      FormWhite solid
      CAS number33419-42-0
      RTECSKC0190000
      Chemical formulaC₂₉H₃₂O₁₃
      Structure formulaStructure formula
      Purity>97% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage +15°C to +30°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14, 3886
      ReferencesDe Lange, A.M., et al. 1995. J. Virol. 69, 2082.
      Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
      Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
      Terada, T., et al. 1993. J. Med. Chem. 36, 1689.
      Wazniak, A.J., et al. 1991. J. Clin. Oncol. 9, 70.
      Einhorn, L.H., et al. 1988. J. Clin. Oncol. 6, 451.
      Issel, B.F. 1982. Cancer Chemother. Pharmacol. 7, 73.