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329600 Erastin - CAS 571203-78-6 - Calbiochem

329600
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Overview

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Key Specifications Table

Empirical FormulaCAS #
C₃₀H₃₁ClN₄O₄ 571203-78-6

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329600-5MG
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      Description
      OverviewA cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality. Shown to bind mitochondrial voltage-dependent anion channels (VDAC) and alter its gating; rapidly induce an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling (EC50 = 6.0 µM in BJ-TERT/LT/ST/RASV12 cells).
      Catalogue Number329600
      Brand Family Calbiochem®
      Synonyms2-(1-(4-(2-(4-Chlorophenoxy)acetyl)-piperazin-1-yl)-ethyl)-3-(2-ethoxyphenyl)-3H-quinazolin-4-one
      References
      ReferencesYagoda, N., et al. 2007. Nature 447, 864.
      Product Information
      CAS number571203-78-6
      FormWhite solid
      Hill FormulaC₃₀H₃₁ClN₄O₄
      Chemical formulaC₃₀H₃₁ClN₄O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationErastin, CAS 571203-78-6, is a cell-permeable compound that binds to VDAC to alter its gating. Induces non-apoptotic cell death in tumor cells harboring activating mutations in RAS-RAF-MEK signaling.
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Erastin - CAS 571203-78-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Erastin - CAS 571203-78-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      329600

      References

      Reference overview
      Yagoda, N., et al. 2007. Nature 447, 864.

      Brochure

      Title
      Mitochondrial Metabolism Modulators (MilliporeSigma)
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-January-2008 JSW
      Synonyms2-(1-(4-(2-(4-Chlorophenoxy)acetyl)-piperazin-1-yl)-ethyl)-3-(2-ethoxyphenyl)-3H-quinazolin-4-one
      DescriptionA cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality. Shown to bind mitochondrial voltage-dependent anion channels (VDAC) and alter its gating; rapidly induce an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling (EC50 = 6.0 µM in BJ-TERT/LT/ST/RASV12 cells).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number571203-78-6
      Chemical formulaC₃₀H₃₁ClN₄O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesYagoda, N., et al. 2007. Nature 447, 864.