01-101 Epidermal growth factor (EGF), culture grade

01-101
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Key ApplicationsSpeciesSource
      CULT Mouse Male mouse submaxillary glands
      Description
      Catalogue Number01-101
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionEpidermal growth factor (EGF), culture grade
      References
      Product Information
      PresentationLyophilized from a solution containing trace sodium acetate
      Quality LevelMQ100
      Applications
      ApplicationThis Epidermal growth factor (EGF), culture grade product is available in a 100 µg format.
      Key Applications
      • Cell Culture
      Biological Information
      SourceMale mouse submaxillary glands
      Entrez Gene Number
      Entrez Gene SummaryEpidermal growth factor has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells of both ectodermal and mesodermal origin. The EGF precursor is believed to exist as a membrane-bound molecule which is proteolytically cleaved to generate the 53-amino acid peptide hormone that stimulates cells to divide.
      Gene Symbol
      • EGF
      • URG
      • urogastrone
      Purification MethodSterilized through a 0.2 micron membrane filter
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01133 # EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture.
      SIZE: 1207 amino acids; 133946 Da
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P01133 ## Contains 9 EGF-like domains. & Contains 9 LDL-receptor class B repeats.
      Stem Cell Type
      • Mouse Embryonic Stem Cells
      • Neural Stem Cells
      • Mesenchymal Stem Cells
      • Induced Pluripotent Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated in a 5-day growth assay using human foreskin fibroblasts
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsLyophilized: Stable for 2 years at 4°C from date of shipment.
      Rehydrated: Stable for 2 months at -20°C. Aliquot to avoid repeated freezing and thawing.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Epidermal growth factor (EGF), culture grade Certificates of Analysis

      TitleLot Number
      EGF (Epidermal Growth Factor)3075370
      EGF (Epidermal Growth Factor)2393899
      EGF (Epidermal Growth Factor) (culture grade)2836588
      EGF (Epidermal Growth Factor) (culture grade) - 20809172080917
      EGF (Epidermal Growth Factor) (culture grade) - 21531372153137
      EGF (Epidermal Growth Factor) - 23678042367804
      EGF (Epidermal Growth Factor) - 19267441926744
      EGF (Epidermal Growth Factor) - 20441282044128
      EGF (Epidermal Growth Factor) - DAM1493332DAM1493332
      EGF (Epidermal Growth Factor) - DAM1548609DAM1548609

      References

      Reference overviewApplicationPub Med ID
      Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction
      Koval, A. P., et al
      J Biol Chem, 273:14780-7 (1998)  1998

      Cell Culture9614078 9614078
      Replacement of tyrosine 1251 in the carboxyl terminus of the insulin-like growth factor-I receptor disrupts the actin cytoskeleton and inhibits proliferation and anchorage-independent growth.
      Blakesley, V A, et al.
      J. Biol. Chem., 273: 18411-22 (1998)  1998

      Show Abstract
      Cell Culture9660809 9660809
      The catalytic domain of protein kinase C chimeras modulates the affinity and targeting of phorbol ester-induced translocation
      Acs, P., et al
      J Biol Chem, 272:22148-53 (1997)  1997

      Immunoblotting (Western)9268359 9268359
      Both the catalytic and regulatory domains of protein kinase C chimeras modulate the proliferative properties of NIH 3T3 cells
      Acs, P., et al
      J Biol Chem, 272:28793-9 (1997)  1997

      Cell Culture9353351 9353351
      Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk
      Beitner-Johnson, D. and LeRoith, D.
      J Biol Chem, 270:5187-90 (1995)  1995

      Cell Culture7534289 7534289
      Insulin stimulates the tyrosine phosphorylation of caveolin
      Mastick, C. C., et al
      J Cell Biol, 129:1523-31 (1995)  1995

      Cell Culture7540611 7540611
      35H, a sequence isolated as a protein kinase C binding protein, is a novel member of the adducin family.
      Dong, L, et al.
      J. Biol. Chem., 270: 25534-40 (1995)  1995

      Show Abstract
      7592723 7592723
      Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation
      Schiemann, W. P., et al
      Proc Natl Acad Sci U S A, 92:5361-5 (1995)  1995

      Cell Culture7777512 7777512
      Epidermal growth factor.
      Cohen, S
      In Vitro Cell. Dev. Biol., 23: 239-46 (1987)  1987

      3553146 3553146

      Related Products & Applications

      Product Families

      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors