538771 Eggmanone - Calbiochem

538771
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₀H₂₀N₂O₂S₃

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      Glass bottle 25 mg
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      Description
      OverviewA cell-permeable thienopyrimidinone compound that acts as a potent and reversible inhibitor of phosphodiesterase IV (IC50 = 72 nM for PDE4D3). Inhibits other PDEs at 40-50-fold higher concentrations (IC50 = 3.00, 3.05 and 4.08 µM for PDE3A, PDE10A2 and PDE11A4, respectively). Displays excellent selectivity over a wide panel of kinases, GPCRs and phosphatases at 10 µM. Shown to robustly activate PKA and block Hedgehog (Hh) signaling downstream of Smoothened. Significantly reduces Gli1 and Ptc1 transcription levels in MEFs and efficiently induces Hh-null phenotype in zebrafish at 2 µM.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number538771
      Brand Family Calbiochem®
      Synonyms3-(2-Methylallyl)-2-((2-oxo-2-(thiophen-2-yl)ethyl)thio)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3H)-one, Phosphodiesterase IV Inhibitor III, Egm
      DescriptionEggmanone
      References
      ReferencesWilliams, C.H., et al. 2015. Cell Reports. 11, 43.
      Product Information
      FormBrown solid
      Hill FormulaC₂₀H₂₀N₂O₂S₃
      Chemical formulaC₂₀H₂₀N₂O₂S₃
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPDE4D3
      Primary Target IC<sub>50</sub>72 nM for PDE4D3
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Eggmanone - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Williams, C.H., et al. 2015. Cell Reports. 11, 43.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-September-2016 JSW
      Synonyms3-(2-Methylallyl)-2-((2-oxo-2-(thiophen-2-yl)ethyl)thio)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3H)-one, Phosphodiesterase IV Inhibitor III, Egm
      DescriptionA cell-permeable thienopyrimidinone compound that acts as a potent and reversible inhibitor of phosphodiesterase IV (IC50 = 72 nM for PDE4D3). Inhibits other PDEs at 40-50-fold higher concentrations (IC50 = 3.00, 3.05 and 4.08 µM for PDE3A, PDE10A2 and PDE11A4, respectively). Displays excellent selectivity over a wide panel of kinases, GPCRs and phosphatases at 10 µM. Shown to robustly activate PKA and block Hedgehog (Hh) signaling downstream of Smoothened. Significantly reduces Gli1 and Ptc1 transcription levels in MEFs and efficiently induces Hh-null phenotype in zebrafish at 2 µM.
      FormBrown solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₀H₂₀N₂O₂S₃
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesWilliams, C.H., et al. 2015. Cell Reports. 11, 43.