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538771 Eggmanone - Calbiochem

A potent & selective PDE4 inhibitor that blocks Hh signaling downstream of Smo. Elicits Hh-null phenotype in zebrafish.

Eggmanone - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(2-Methylallyl)-2-((2-oxo-2-(thiophen-2-yl)ethyl)thio)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3H)-one, Phosphodiesterase IV Inhibitor III, Egm

Primary Target: PDE4D3
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₀H₂₀N₂O₂S₃

Products

Catalog NumberPackaging Qty/Pack
5.38771.0001 Glass bottle 25 mg
Description
OverviewA cell-permeable thienopyrimidinone compound that acts as a potent and reversible inhibitor of phosphodiesterase IV (IC50 = 72 nM for PDE4D3). Inhibits other PDEs at 40-50-fold higher concentrations (IC50 = 3.00, 3.05 and 4.08 µM for PDE3A, PDE10A2 and PDE11A4, respectively). Displays excellent selectivity over a wide panel of kinases, GPCRs and phosphatases at 10 µM. Shown to robustly activate PKA and block Hedgehog (Hh) signaling downstream of Smoothened. Significantly reduces Gli1 and Ptc1 transcription levels in MEFs and efficiently induces Hh-null phenotype in zebrafish at 2 µM.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number538771
Brand Family Calbiochem®
Synonyms3-(2-Methylallyl)-2-((2-oxo-2-(thiophen-2-yl)ethyl)thio)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3H)-one, Phosphodiesterase IV Inhibitor III, Egm
DescriptionEggmanone
References
ReferencesWilliams, C.H., et al. 2015. Cell Reports. 11, 43.
Product Information
FormBrown solid
Hill FormulaC₂₀H₂₀N₂O₂S₃
Chemical formulaC₂₀H₂₀N₂O₂S₃
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetPDE4D3
Primary Target IC<sub>50</sub>72 nM for PDE4D3
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Eggmanone - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Williams, C.H., et al. 2015. Cell Reports. 11, 43.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-September-2016 JSW
Synonyms3-(2-Methylallyl)-2-((2-oxo-2-(thiophen-2-yl)ethyl)thio)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3H)-one, Phosphodiesterase IV Inhibitor III, Egm
DescriptionA cell-permeable thienopyrimidinone compound that acts as a potent and reversible inhibitor of phosphodiesterase IV (IC50 = 72 nM for PDE4D3). Inhibits other PDEs at 40-50-fold higher concentrations (IC50 = 3.00, 3.05 and 4.08 µM for PDE3A, PDE10A2 and PDE11A4, respectively). Displays excellent selectivity over a wide panel of kinases, GPCRs and phosphatases at 10 µM. Shown to robustly activate PKA and block Hedgehog (Hh) signaling downstream of Smoothened. Significantly reduces Gli1 and Ptc1 transcription levels in MEFs and efficiently induces Hh-null phenotype in zebrafish at 2 µM.
FormBrown solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₀H₂₀N₂O₂S₃
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesWilliams, C.H., et al. 2015. Cell Reports. 11, 43.