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324412 Dynamin Inhibitor III, Phthaladyn-23 - Calbiochem

324412
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₂H₁₂ClN₃O₇

Pricing & Availability

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324412-10MG
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      Description
      OverviewA cell-permeable phthalimide compound that is reported to inhibit dynamin GTPase activity (IC50 = 17.4 and 63 µM using purified sheep brain dynamin I and recombinant dynamin II, respectively) in a GTP-competitive manner. Shown to block K+-induced SVE (synaptic vesicle endocytosis) of FM4-64 dye into rat brain synaptosomes (IC50 = 12.9 µM), while being ineffective at 30 µM against RME (receptor-mediated endocytosis) of transferrin into human osteosarcoma epithelial U2OS cells, presumably due to poor dynamin II inhibitory potency and/or rapid efflux and/or limited permeability in this cell line.
      Catalogue Number324412
      Brand Family Calbiochem®
      Synonyms4-Chloro-2-((2-(3-nitrophenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carbonyl)-amino)-benzoic acid
      References
      ReferencesOdell, L.R., et al. 2010. J. Med. Chem. 53, 5267.
      Product Information
      FormLight yellow to beige solid
      Hill FormulaC₂₂H₁₂ClN₃O₇
      Chemical formulaC₂₂H₁₂ClN₃O₇
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Dynamin Inhibitor III, Phthaladyn-23 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Dynamin Inhibitor III, Phthaladyn-23 - Calbiochem Certificates of Analysis

      TitleLot Number
      324412

      References

      Reference overview
      Odell, L.R., et al. 2010. J. Med. Chem. 53, 5267.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2015 JSW
      Synonyms4-Chloro-2-((2-(3-nitrophenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carbonyl)-amino)-benzoic acid
      DescriptionA cell-permeable phthalimide compound that is reported to inhibit dynamin GTPase activity (IC50 = 17.4 and 63 µM using purified sheep brain dynamin I and recombinant dynamin II, respectively) in a GTP-competitive manner. Shown to block K+-induced SVE (synaptic vesicle endocytosis) of FM4-64 dye into rat brain synaptosomes (IC50 = 12.9 µM), while being ineffective at 30 µM against RME (receptor-mediated endocytosis) of transferrin into human osteosarcoma epithelial U2OS cells, presumably due to poor dynamin II inhibitory potency and/or rapid efflux and/or limited permeability in this cell line.
      FormLight yellow to beige solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₂H₁₂ClN₃O₇
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (7 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesOdell, L.R., et al. 2010. J. Med. Chem. 53, 5267.