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287895 Drosophila Antennapedia Homeo-Domain (43-58) - Calbiochem

The membrane translocation signal sequence from Drosophila Antennapedia homeo-domain (43-58) that is reported to act as an inhibitor of protein kinase G Iα (Ki = 970 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: DT-5, RQIKIWFQNRRMKWKK, PKG Inhibitor V

Primary Target: PKG1α
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₀₄H₁₆₈N₃₄O₂₀S
Description
OverviewThe membrane translocation signal sequence from Drosophila Antennapedia homeo-domain (43-58) that is reported to act as an inhibitor of protein kinase G Iα (Ki = 970 nM). Does not exhibit significant inhibition against protein kinase A (PKA) (Ki = 107 µM). May be useful for intracellular delivery of highly charged peptides by covalent attachment.
Catalogue Number287895
Brand Family Calbiochem®
SynonymsDT-5, RQIKIWFQNRRMKWKK, PKG Inhibitor V
References
ReferencesDostman, W.R.G., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 14772.
Derossi, D., et al. 1998. Trends Cell Biol. 8, 84.
Product Information
ATP CompetitiveN
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₀₄H₁₆₈N₃₄O₂₀S
Chemical formulaC₁₀₄H₁₆₈N₃₄O₂₀S
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKG1α
Primary Target K<sub>i</sub>970 nM against protein kinase G Iα
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number GTIN
287895

Documentation

Drosophila Antennapedia Homeo-Domain (43-58) - Calbiochem Certificates of Analysis

TitleLot Number
287895

References

Reference overview
Dostman, W.R.G., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 14772.
Derossi, D., et al. 1998. Trends Cell Biol. 8, 84.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-June-2008 RFH
SynonymsDT-5, RQIKIWFQNRRMKWKK, PKG Inhibitor V
DescriptionThe membrane translocation signal sequence from Drosophila Antennapedia homeo-domain (43-58) that has been shown to inhibit protein kinase G Iα (PKG Iα) (Ki = 970 nM). Does not exhibit significant inhibition against protein kinase A (PKA) (Ki = 107 µM). May also be useful for intracellular delivery of highly charged peptides by covalent attachment.
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₀₄H₁₆₈N₃₄O₂₀S
Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesDostman, W.R.G., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 14772.
Derossi, D., et al. 1998. Trends Cell Biol. 8, 84.