233630 Cryptotanshinone - CAS 35825-57-1 - Calbiochem

233630
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Overview

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Key Specifications Table

Empirical FormulaCAS #
C₁₉H₂₀O₃ 35825-57-1

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233630-10MG
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      Plastic ampoule 10 mg
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      Description
      OverviewCryptotanshinone, a cell-permeable diterpene quinone and naturally occurring herbal constituent of Salvia miltiorrhiza Bunge (Danshen), is shown to inhibit the constitutive STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells (>90% inhibition in 1 h at 7 µM) independent of the IL-6/JAK/STAT3 signaling pathway, resulting in a blockage of STAT3 dimerization, nuclear translocation, and STAT3-dependent transcription activity (by ~80% in 24 h at 7 µM). Cryptotanshinone is also reported to deplete cellular ATP level (by 75% in 12 h at 20 µM in C2C12 myotubes), resulting in an indirect activation of cellular AMPK pathways and an enhancement of insulin-stimulated cellular glucose uptake in C2C12 myotubes and 3T3-L1 adipocytes (by ~1.3- and 1.9-fold, respectively). Cryptotanshinone is demonstrated to be an orally active hypoglycemic agent in ob/ob mice, db/db mice, and ZDF rats in vivo (600 mg/kg/day).
      Catalogue Number233630
      Brand Family Calbiochem®
      SynonymsAMPK Signaling Activator VIII
      References
      ReferencesShin, D.S., et al. 2009. Cancer Res. 69, 193.
      Kim, E.J., et al. 2007. Mol. Pharmacol. 72, 62.
      Product Information
      CAS number35825-57-1
      FormOrange solid
      Hill FormulaC₁₉H₂₀O₃
      Chemical formulaC₁₉H₂₀O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25-36/37-45

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing and gloves.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cryptotanshinone - CAS 35825-57-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Cryptotanshinone - CAS 35825-57-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      233630

      References

      Reference overview
      Shin, D.S., et al. 2009. Cancer Res. 69, 193.
      Kim, E.J., et al. 2007. Mol. Pharmacol. 72, 62.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-September-2009 RFH
      SynonymsAMPK Signaling Activator VIII
      DescriptionCryptotanshinone, a cell-permeable diterpene quinone and naturally occurring herbal constituent of Salvia miltiorrhiza Bunge (Danshen), is shown to inhibit the constitutive STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells (>90% inhibition in 1 h at 7 µM) independent of the IL-6/JAK/STAT3 signaling pathway, resulting in a blockage of STAT3 dimerization, nuclear translocation, and STAT3-dependent transcription activity (by ~80% in 24 h at 7 µM). Cryptotanshinone is also reported to deplete cellular ATP level (by 75% in 12 h at 20 µM in C2C12 myotubes), resulting in an indirect activation of cellular AMPK pathways and an enhancement of insulin-stimulated cellular glucose uptake in C2C12 myotubes and 3T3-L1 adipocytes (by ~1.3- and 1.9-fold, respectively). Cryptotanshinone is demonstrated to be an orally active hypoglycemic agent in ob/ob mice, db/db mice, and ZDF rats in vivo (600 mg/kg/day).
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number35825-57-1
      Chemical formulaC₁₉H₂₀O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml) or Ethanol (1 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesShin, D.S., et al. 2009. Cancer Res. 69, 193.
      Kim, E.J., et al. 2007. Mol. Pharmacol. 72, 62.