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504480 Conantokin G - CAS 93438-65-4 - Calbiochem

504480
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₈₈H₁₃₉N₂₆O₄₄: GE(Gla)(Gla)LQ(Gla)NQ(Gla)LIR(Gla)KSN-NH₂ 93438-65-4

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      Glass bottle 100 μg
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      Description
      OverviewThe most selective and potent non-competitive antagonist among the members of the conantokin peptide family for NR2B-containing NMDAR channels (Ki = 0.8 µM with close to 100% inhibition of NR1/NR2B mediated current). Widely used for studies related to NMDAR neurotransmissions in both peripheral and center nervous systems.
      Catalogue Number504480
      Brand Family Calbiochem®
      SynonymsGly-Glu-γ-CarboxyGlu-γ-CarboxyGlu-Leu-Gln-γ-CarboxyGlu-Asn-Gln-γ-CarboxyGlu-Leu-Ile-Arg-γ-CarboxyGlu-Lys-Ser-Asn-NH2
      References
      ReferencesSheng, Z., et al. 2007. Neuropharmacology. 53, 145.
      Sheng, Z., et al. 2009. Neuropharmacology. 57, 127.
      Zhou, L., et al. 1996. J. Neurochemistry. 66, 620.
      Hammerland, L., et al. 1992. Eur. J. Pharmacol. 226, 239.
      Mena, E., et al. 1990. Neurosci Lett. 118, 241.
      Donevan, D., et al. 2000. Mol Pharmacol. 58, 614.
      Product Information
      CAS number93438-65-4
      FormWhite powder
      Hill FormulaC₈₈H₁₃₉N₂₆O₄₄: GE(Gla)(Gla)LQ(Gla)NQ(Gla)LIR(Gla)KSN-NH₂
      Chemical formulaC₈₈H₁₃₉N₂₆O₄₄: GE(Gla)(Gla)LQ(Gla)NQ(Gla)LIR(Gla)KSN-NH₂
      Sold on the basis of peptide contentY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNMDA receptors
      Primary Target K<sub>i</sub>0.8 µM
      Purity≥95% by HPLC
      Physicochemical Information
      Peptide ContentY
      Peptide SequenceGly-Glu-γ-CarboxyGlu-γ-CarboxyGlu-Leu-Gln-γ-CarboxyGlu-Asn-Gln-γ-CarboxyGlu-Leu-Ile-Arg-γ-CarboxyGlu-Lys-Ser-Asn-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Conantokin G - CAS 93438-65-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Sheng, Z., et al. 2007. Neuropharmacology. 53, 145.
      Sheng, Z., et al. 2009. Neuropharmacology. 57, 127.
      Zhou, L., et al. 1996. J. Neurochemistry. 66, 620.
      Hammerland, L., et al. 1992. Eur. J. Pharmacol. 226, 239.
      Mena, E., et al. 1990. Neurosci Lett. 118, 241.
      Donevan, D., et al. 2000. Mol Pharmacol. 58, 614.

      Brochure

      Title
      NPI Flyer- Epigenetics and Nuclear Function Feature (EMD)
      Neuroscience Solutions for productive research
      New Products - Antibodies, Small Molecule, Inhibitors
      Pathways and Biomarkers of Glutamatergic Synapse Flyer (EMD)

      Technical Info

      Title
      White Paper: Further considerations of antibody validation and usage. (EMD)
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-September-2014 JSW
      SynonymsGly-Glu-γ-CarboxyGlu-γ-CarboxyGlu-Leu-Gln-γ-CarboxyGlu-Asn-Gln-γ-CarboxyGlu-Leu-Ile-Arg-γ-CarboxyGlu-Lys-Ser-Asn-NH2
      DescriptionThe most selective and potent non-competitive antagonist among the members of the conantokin peptide family for NR2B-containing NMDAR channels (Ki = 0.8 µM with close to 100% inhibition of NR1/NR2B mediated current). Widely used for studies related to NMDAR neurotransmissions in both peripheral and center nervous systems.
      FormWhite powder
      CAS number93438-65-4
      Chemical formulaC₈₈H₁₃₉N₂₆O₄₄: GE(Gla)(Gla)LQ(Gla)NQ(Gla)LIR(Gla)KSN-NH₂
      Peptide SequenceGly-Glu-γ-CarboxyGlu-γ-CarboxyGlu-Leu-Gln-γ-CarboxyGlu-Asn-Gln-γ-CarboxyGlu-Leu-Ile-Arg-γ-CarboxyGlu-Lys-Ser-Asn-NH₂
      Purity≥95% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSheng, Z., et al. 2007. Neuropharmacology. 53, 145.
      Sheng, Z., et al. 2009. Neuropharmacology. 57, 127.
      Zhou, L., et al. 1996. J. Neurochemistry. 66, 620.
      Hammerland, L., et al. 1992. Eur. J. Pharmacol. 226, 239.
      Mena, E., et al. 1990. Neurosci Lett. 118, 241.
      Donevan, D., et al. 2000. Mol Pharmacol. 58, 614.