GF109 Ciliary Neurotrophic Factor Protein, Recombinant human

GF109
20 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      SpeciesSourcePurity
      Human E.coli Greater than 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of CNTF.
      Description
      Catalogue NumberGF109
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionCiliary Neurotrophic Factor Protein, Recombinant human
      OverviewCiliary Neurotrophic Factor (CNTF) is a potent neural factor that was originally characterized as a survivability factor for chick ciliary neurons in vitro. CNTF also has been shown to promote survivability and differentiation of other neural cell types. Recombinant Human CNTF is a 22.7 kDa protein containing 199 amino acid residues.
      Alternate Names
      • CNTF
      References
      Product Information
      PresentationThe sterile filtered solution was lyophilized from 10 mM Citric Acid, pH 3.0 + 75 mM sodium chloride.
      Quality LevelMQ100
      Applications
      ApplicationThe human Ciliary Neurotrophic Factor (or CNTF protein) is a potent neural factor that was originally characterized as a survivability factor for chick ciliary neurons in vitro.
      Biological Information
      PurityGreater than 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of CNTF.
      SourceE.coli
      Specific ActivityThe ED50 as determined by the dose-dependent proliferation of human TF-1 cells is 50-150 ng/mL.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. In addition to the predominant monocistronic transcript originating from this locus, the gene is also co-transcribed with the upstream ZFP91 gene. Co-transcription from the two loci results in a transcript that contains a complete coding region for the zinc finger protein but lacks a complete coding region for ciliary neurotrophic factor.
      Gene Symbol
      • CNTF
      • HCNTF
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P26441 # CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
      SIZE: 200 amino acids; 22931 Da
      SUBUNIT: Homodimer.
      SUBCELLULAR LOCATION: Cytoplasm.
      TISSUE SPECIFICITY: Nervous system.
      SIMILARITY: SwissProt: P26441 ## Belongs to the CNTF family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized powder is stable for a few weeks at room temperature, but best stored at -20°C. Reconstitute in 5 mM NaP, pH 7.5 to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use. Reconstituted human CNTF should be stored in undiluted aliquots at -20°C. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size20 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ciliary Neurotrophic Factor Protein, Recombinant human SDS

      Title

      Safety Data Sheet (SDS) 

      Ciliary Neurotrophic Factor Protein, Recombinant human Certificates of Analysis

      TitleLot Number
      RECOMBINANT HUMAN CILIARY NEUROTROPHIC FACTOR3098921
      RECOMBINANT HUMAN CILIARY NEUROTROPHIC FACTOR2925407
      RECOMBINANT HUMAN CILIARY NEUROTROPHIC FACTOR2483183
      RECOMBINANT HUMAN CILIARY NEUROTROPHIC FACTOR2905626
      RECOMBINANT HUMAN CILIARY NEUROTROPHIC FACTOR - 21231172123117
      RECOMBINANT HUMAN CILIARY NEUROTROPHIC FACTOR - 23283182328318
      RECOMBINANT HUMAN CILIARY NEUROTROPHIC FACTOR - 21434532143453
      RECOMBINANT HUMAN CILIARY NEUROTROPHIC FACTOR - 22626482262648
      RECOMBINANT HUMAN CILIARY NEUROTROPHIC FACTOR - 23157032315703
      RECOMBINANT HUMAN CILIARY NEUROTROPHIC FACTOR -27778942777894

      References

      Reference overviewApplicationPub Med ID
      beta-Defensins chemoattract macrophages and mast cells but not lymphocytes and dendritic cells: CCR6 is not involved.
      Afsaneh Soruri,Jasmin Grigat,Ulf Forssmann,Joachim Riggert,Jörg Zwirner
      European journal of immunology  37  2007

      Show Abstract
      17705135 17705135
      PKCepsilon induces astrocyte stellation by modulating multiple cytoskeletal proteins and interacting with Rho A signalling pathways: implications for neuroinflammation.
      Miguel Burgos,Soledad Calvo,Francisca Molina,Cecilia F Vaquero,Allen Samarel,Juan Llopis,Pedro Tranque
      The European journal of neuroscience  25  2007

      Show Abstract
      17331203 17331203
      CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK
      Watt, Matthew J, et al
      Nat Med, 12:541-8 (2006)  2006

      16604088 16604088
      Activation of cellular invasion by trefoil peptides and src is mediated by cyclooxygenase- and thromboxane A2 receptor-dependent signaling pathways.
      S Rodrigues,Q D Nguyen,S Faivre,E Bruyneel,L Thim,B Westley,F May,G Flatau,M Mareel,C Gespach,S Emami
      FASEB journal : official publication of the Federation of American Societies for Experimental Biology  15  2001

      Show Abstract
      11427483 11427483
      Induction of scattering and cellular invasion by trefoil peptides in src- and RhoA-transformed kidney and colonic epithelial cells.
      S Emami,N Le Floch ,E Bruyneel,L Thim,F May,B Westley,M Rio,M Mareel,C Gespach
      FASEB journal : official publication of the Federation of American Societies for Experimental Biology  15  2001

      Show Abstract
      Cell Culture11156951 11156951
      Evaluation of signal transduction pathways in chemoattractant-induced human monocyte chemotaxis.
      J S Fine,H D Byrnes,P J Zavodny,R W Hipkin
      Inflammation  25  2001

      Show Abstract
      11321360 11321360

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      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors