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220285 Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem

220285
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₁H₁₈NO₄Cl 3895-92-9

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220285-5MG
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      Plastic ampoule 5 mg
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      Description
      OverviewNaturally-occurring alkaloid. Potent, selective, and cell-permeable inhibitor of protein kinase C (IC50 = 660 nM). Acts on the catalytic domain of PKC. A competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.
      Catalogue Number220285
      Brand Family Calbiochem®
      References
      ReferencesKandasamy, R.A., et al. 1995. J. Biol. Chem. 270 29209.
      Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
      Barg, J., et al. 1992. J. Neurochem. 59, 1145.
      Herbert, J.M., et al. 1990. Biochem. Biophys. Res. Commun. 172, 993.
      Ko, F., et al. 1990. Biochim. Biophys. Acta 1052, 360.
      Walterova, D., et al. J. Med. Chem. 24, 1100.
      Product Information
      CAS number3895-92-9
      ATP CompetitiveN
      FormLight yellow to yellow solid
      Hill FormulaC₂₁H₁₈NO₄Cl
      Chemical formulaC₂₁H₁₈NO₄Cl
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKC
      Primary Target IC<sub>50</sub>660 nM
      Purity≥97% by NMR
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSFL9200000
      Safety Information
      R PhraseR: 20/21/22-36/37/38

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      220285

      References

      Reference overview
      Kandasamy, R.A., et al. 1995. J. Biol. Chem. 270 29209.
      Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
      Barg, J., et al. 1992. J. Neurochem. 59, 1145.
      Herbert, J.M., et al. 1990. Biochem. Biophys. Res. Commun. 172, 993.
      Ko, F., et al. 1990. Biochim. Biophys. Acta 1052, 360.
      Walterova, D., et al. J. Med. Chem. 24, 1100.

      Brochure

      Title
      PKC Pathway Poster PDF ( 676 KB )
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2008 RFH
      DescriptionNaturally occurring alkaloid. Cell-permeable, selective inhibitor of protein kinase C (IC50 = 660 nM). Acts on the catalytic domain irrespective of the attachment of the regulatory domain. Material is a competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.
      FormLight yellow to yellow solid
      CAS number3895-92-9
      RTECSFL9200000
      Chemical formulaC₂₁H₁₈NO₄Cl
      Structure formulaStructure formula
      Purity≥97% by NMR
      SolubilityDMSO (10 mg/ml) or H₂O (1 mg/ml). Heating to 40-50°C with gentle agitation may be necessary to achieve complete solubilization. Further dilute with buffer just prior to use.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Harmful
      Merck USA index14, 2051
      ReferencesKandasamy, R.A., et al. 1995. J. Biol. Chem. 270 29209.
      Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
      Barg, J., et al. 1992. J. Neurochem. 59, 1145.
      Herbert, J.M., et al. 1990. Biochem. Biophys. Res. Commun. 172, 993.
      Ko, F., et al. 1990. Biochim. Biophys. Acta 1052, 360.
      Walterova, D., et al. J. Med. Chem. 24, 1100.