238806 Cdk2/9 Inhibitor - CAS 507487-89-0 - Calbiochem

238806
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₄H₁₂N₆O₂S 507487-89-0

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238806-5MG
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      Plastic ampoule 5 mg
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      Description
      OverviewA cell-permeable aminopyrimidinyl compound that acts as a potent and ATP-competitive inhibitor of Cdk2/E and Cdk9/T1 (Ki = 2 nM and 4 nM, respectively). It also inhibits GSK-3β, Cdk4/D1, Cdk7/H, Cdk1/B, and Abl at higher concentrations (Ki = 20, 53, 70, 80, and 160 nM, respectively), but exhibits little activity towards 9 other kinases (Ki > 1.0 µM). Shown to inhibit phosphorylation of cellular Cdk substrates, pRb and RNA polymerase II, and Cdk2-mediated S-phase transition.
      Catalogue Number238806
      Brand Family Calbiochem®
      Synonyms(4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(3-nitrophenyl)amine, Cdk7 Inhibitor III
      References
      ReferencesKontopidis, G., et al. 2006. Chem. Biol. 13, 201.
      Wang, S., et al. 2004. J. Med. Chem. 47, 1662.
      Product Information
      CAS number507487-89-0
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₁₄H₁₂N₆O₂S
      Chemical formulaC₁₄H₁₂N₆O₂S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCdk2/E and Cdk9/T1
      Primary Target K<sub>i</sub>2 nM and 4 nM against Cdk2/E and Cdk9/T1, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cdk2/9 Inhibitor - CAS 507487-89-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Cdk2/9 Inhibitor - CAS 507487-89-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      238806

      References

      Reference overview
      Kontopidis, G., et al. 2006. Chem. Biol. 13, 201.
      Wang, S., et al. 2004. J. Med. Chem. 47, 1662.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-April-2011 RFH
      Synonyms(4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(3-nitrophenyl)amine, Cdk7 Inhibitor III
      DescriptionA cell-permeable aminopyrimidinyl compound that acts as a potent and ATP-competitive inhibitor of Cdk2/E and Cdk9/T1 (Ki = 2 nM and 4 nM, respectively). It also inhibits GSK-3β, Cdk4/D1, Cdk7/H, Cdk1/B, and Abl at higher concentrations (Ki = 20, 53, 70, 80, and 160 nM, respectively), but exhibits little activity towards 9 other kinases (Ki > 1.0 µM). Shown to inhibit phosphorylation of cellular Cdk substrates, pRb and RNA polymerase II, and Cdk2-mediated S-phase transition.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number507487-89-0
      Chemical formulaC₁₄H₁₂N₆O₂S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKontopidis, G., et al. 2006. Chem. Biol. 13, 201.
      Wang, S., et al. 2004. J. Med. Chem. 47, 1662.