Product Information
Applications
Biological Information
Primary Targetcathepsin K
Primary Target K<sub>i</sub>22 nM against cathepsin K
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceCbz-Leu-NH-CH₂-CO-CH₂-NH-Leu-Cbz
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Cathepsin K Inhibitor I - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cathepsin K Inhibitor I - Calbiochem Certificates of Analysis

TitleLot Number
219377

References

Reference overview
Claveau, D., et al. 2000. Biochem. Pharmacol. 60, 759.
LaLonde, J.M., et al. 1999. Biochemistry 38, 862.
Yamashita, D.S., et al. 1997. J. Am. Chem. Soc. 119, 11351.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-June-2008 RFH
Synonyms1,3-Bis(CBZ-Leu-NH)-2-propanone, 1,3-Bis(N-carbobenzoyloxy-L-leucyl)amino Acetone
DescriptionA cell-permeable, symmetrical bis(acylamino)ketone compound that acts as a potent, selective, reversible inhibitor of cathepsin K (Ki, = 22 nM). Also shown to inhibit cathepsin K in stably transfected CHO cells (IC50 = 134 nM). Reported to bind to cathepsin K and span both the S- and S'- subsites. Inhibits papain (Ki >10 µM), trypsin (Ki >50 µM), and chymotrypsin (Ki >50 µM) only at higher concentrations. Exhibits greater selectivity for cysteine proteases of the papain family (Ki = 340 nM, 890 nM, and 1-3 µM for cathepsin L, cathepsin S, and cathepsin B, respectively).
FormOff-white lyophilized solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₁H₄₂N₄O₇
Peptide SequenceCbz-Leu-NH-CH₂-CO-CH₂-NH-Leu-Cbz
Purity≥95% by HPLC
SolubilityMethanol (1 mg/ml) or DMSO
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesClaveau, D., et al. 2000. Biochem. Pharmacol. 60, 759.
LaLonde, J.M., et al. 1999. Biochemistry 38, 862.
Yamashita, D.S., et al. 1997. J. Am. Chem. Soc. 119, 11351.

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Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors