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218833 Caspase-6 Inhibitor XII, pep419 - Calbiochem

The Caspase-6 Inhibitor XII, pep419 controls the biological activity of Caspase-6. This small molecule/inhibitor is primarily used for Cancer applications.

Caspase-6 Inhibitor XII, pep419 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Caspase inhibitor, pep419

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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₉₉H₁₆₂N₃₀O₂₉S
Description
OverviewAn 18-mer synthetic peptide that acts as a selective, non-competitive inhibitor of caspase-6 (IC50 = 8.6 µM). Blocks the activity of processed caspase-6 as evidenced by its reduced ability to process VEID-AMC substrate. Exhibits only a trivial effect on caspase-9 and 7 and does not affect the activities of caspases 1, 2, 3, 4, 5, 8, and 10. Acts as an allosteric peptide ligand that binds outside the active site of the enzyme and impairs its activity. Pep419 is shown to bind as a dimer to an allosteric site of caspase-6 zymogen resulting in its tetramerizaton and stabilization. Its binding site is shown to be distinct from the substrate binding site of the enzyme. Electroporation has been shown to enable the entry of 5-carboxyfluorescein-labeled peptide into SKNAS bone marrow neuroblastoma cells.
Catalogue Number218833
Brand Family Calbiochem®
SynonymsCaspase inhibitor, pep419
References
ReferencesStanger, K., et al. 2012. Nat. Chem. Bio. 8, 655.
Product Information
FormWhite powder
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₉₉H₁₆₂N₃₀O₂₉S
Chemical formulaC₉₉H₁₆₂N₃₀O₂₉S
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Peptide SequenceAc-TEKEKGRLHCVEWTILER-NH2
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number GTIN
218833

Documentation

Caspase-6 Inhibitor XII, pep419 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Caspase-6 Inhibitor XII, pep419 - Calbiochem Certificates of Analysis

TitleLot Number
218833

References

Reference overview
Stanger, K., et al. 2012. Nat. Chem. Bio. 8, 655.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision21-June-2013 JSW
SynonymsCaspase inhibitor, pep419
DescriptionAn 18-mer synthetic peptide that acts as a selective, non-competitive inhibitor of caspase-6 (IC50 = 8.6 µM). Blocks the activity of processed caspase-6 as evidenced by its reduced ability to process VEID-AMC substrate. Exhibits only a trivial effect on caspase-9 and 7 and does not affect the activities of caspases 1, 2, 3, 4, 5, 8, and 10. Acts as an allosteric peptide ligand that binds outside the active site of the enzyme and impairs its activity. Pep419 is shown to bind as a dimer to an allosteric site of caspase-6 zymogen resulting in its tetramerizaton and stabilization. Its binding site is shown to be distinct from the substrate binding site of the enzyme. Electroporation has been shown to enable the entry of 5-carboxyfluorescein-labeled peptide into SKNAS bone marrow neuroblastoma cells.
FormWhite powder
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₉₉H₁₆₂N₃₀O₂₉S
Peptide SequenceAc-TEKEKGRLHCVEWTILER-NH2
Purity≥95% by HPLC
SolubilityH₂O (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesStanger, K., et al. 2012. Nat. Chem. Bio. 8, 655.