208725 Calphostin C, Cladosporium cladosporioides - CAS 121263-19-2 - Calbiochem

208725
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₄₄H₃₈O₁₄ 121263-19-2

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208725-100UG
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      208725-50UG
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          Description
          OverviewA cell permeable, highly specific inhibitor of protein kinase C (IC50 = 50 nM) that interacts with the protein’s regulatory domain by competing at the binding site of diacylglycerol and phorbol esters. Does not compete with Ca2+ or phospholipids. At higher concentrations inhibits myosin light chain kinase (IC50 > 5 µM), protein kinase A (IC50 > 50 µM), protein kinase G (IC50 > 25 µM), and p60v-src (IC50 > 50 µM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Requires brief exposure to light for activation.
          Catalogue Number208725
          Brand Family Calbiochem®
          SynonymsUCN-1028c
          References
          ReferencesJarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
          Svetlov, S., and Nigami, S. 1993. Biochim. Biophys. Acta 1177, 75.
          Gopalakrishna, R., et al. 1992. FEBS Lett. 314, 149.
          Shimamato, H., et al. 1992. Br. J. Pharmacol. 107, 282.
          Bruns, R.F., et al. 1991. Biochem. Biophys. Res. Commun. 176, 288.
          Tamaoki, T., et al. 1990. Biotechnology 8, 732.
          Kobayashi, E., et al. 1989. Biochem. Biophys. Res. Commun. 159, 548.
          Product Information
          CAS number121263-19-2
          ATP CompetitiveN
          FormLight brown lyophilized solid
          Hill FormulaC₄₄H₃₈O₁₄
          Chemical formulaC₄₄H₃₈O₁₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetPKC
          Primary Target IC<sub>50</sub>50 nM against protein kinase C
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Calphostin C, Cladosporium cladosporioides - CAS 121263-19-2 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Calphostin C, Cladosporium cladosporioides - CAS 121263-19-2 - Calbiochem Certificates of Analysis

          TitleLot Number
          208725

          References

          Reference overview
          Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
          Svetlov, S., and Nigami, S. 1993. Biochim. Biophys. Acta 1177, 75.
          Gopalakrishna, R., et al. 1992. FEBS Lett. 314, 149.
          Shimamato, H., et al. 1992. Br. J. Pharmacol. 107, 282.
          Bruns, R.F., et al. 1991. Biochem. Biophys. Res. Commun. 176, 288.
          Tamaoki, T., et al. 1990. Biotechnology 8, 732.
          Kobayashi, E., et al. 1989. Biochem. Biophys. Res. Commun. 159, 548.

          Brochure

          Title
          PKC Pathway Poster PDF ( 676 KB )

          Citations

          Title
        • Martha E. O'Donnnell, et al. (2005) Arginine Vasopressin Stimulation of Cerebral Microvascular Endothelial Cell Na-K-Cl Cotransporter Activity is V1 Receptor and [Ca] Dependent. American Journal of Physiology Cell Physiology 289, C283-C292.
        • Yi Dai, et al. (2004) Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. Journal of Neuroscience 24, 4293-4299.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-May-2008 RFH
          SynonymsUCN-1028c
          DescriptionCell-permeable, highly specific inhibitor of protein kinase C (IC50 = 50 nM) that interacts with the protein's regulatory domain by competing at the binding site of diacylglycerol and phorbol esters. At higher concentrations inhibits myosin light chain kinase (IC50 > 5 µM), protein kinase A (IC50 > 50 µM), protein kinase G (IC50 > 25 µM), and p60v-src protein tyrosine kinase (IC50 > 50 µM). Does not compete with Ca2+ or phospholipids. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Inhibition of PKC is dependent on exposure to light in cell-free systems. Ordinary fluorescent light is sufficient for full activation.
          FormLight brown lyophilized solid
          CAS number121263-19-2
          Chemical formulaC₄₄H₃₈O₁₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (1 mg/ml) or Ethanol
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesJarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
          Svetlov, S., and Nigami, S. 1993. Biochim. Biophys. Acta 1177, 75.
          Gopalakrishna, R., et al. 1992. FEBS Lett. 314, 149.
          Shimamato, H., et al. 1992. Br. J. Pharmacol. 107, 282.
          Bruns, R.F., et al. 1991. Biochem. Biophys. Res. Commun. 176, 288.
          Tamaoki, T., et al. 1990. Biotechnology 8, 732.
          Kobayashi, E., et al. 1989. Biochem. Biophys. Res. Commun. 159, 548.
          Citation
        • Martha E. O'Donnnell, et al. (2005) Arginine Vasopressin Stimulation of Cerebral Microvascular Endothelial Cell Na-K-Cl Cotransporter Activity is V1 Receptor and [Ca] Dependent. American Journal of Physiology Cell Physiology 289, C283-C292.
        • Yi Dai, et al. (2004) Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. Journal of Neuroscience 24, 4293-4299.