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504713 CPCCOEt - CAS 179067-99-3 - Calbiochem

CPCCOEt - CAS 179067-99-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E)-Ethyl 1,1a,7,7a-tetrahydro-7-(hydroxyimino)cyclopropa[b]chromene-1a-carboxylate, mGlu₁ Antagonist, CPCCOEt

Primary Target: mGlu₁ receptors
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
179067-99-3C₁₃H₁₃NO₄
Description
OverviewA potent, negative allosteric modulator selective for mGlu1 receptors (IC50 = 6.5 µM). No effect on other mGlu subtype receptors and ionotropic glutamate receptors at concentrations less than 100 µM. Acts by inhibiting an intramolecular interaction between the agonist-bound extracellular domain and the transmembrane domain. Widely used for studies related to peripheral pain and central pain pathways.
Catalogue Number504713
Brand Family Calbiochem®
Synonyms(E)-Ethyl 1,1a,7,7a-tetrahydro-7-(hydroxyimino)cyclopropa[b]chromene-1a-carboxylate, mGlu₁ Antagonist, CPCCOEt
References
ReferencesLuongo L, et al. 2013. Neuropharmacol. 66, 317.
Jin, Y., et al. 2012. Pain Res. Treat. 2012, 915706.
Tappe-Theodor, A., 2011. Mol Pain. 7, 38.
Litschig, S., et al. 1999. Mol. Pharmacol. 55, 453.
Annoura, H., et al. 1996. Bioorg. Med. Chem. Lett. 6, 763.
Product Information
CAS number179067-99-3
FormWhite powder
Hill FormulaC₁₃H₁₃NO₄
Chemical formulaC₁₃H₁₃NO₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetmGlu₁ receptors
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number GTIN
504713

Documentation

CPCCOEt - CAS 179067-99-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Luongo L, et al. 2013. Neuropharmacol. 66, 317.
Jin, Y., et al. 2012. Pain Res. Treat. 2012, 915706.
Tappe-Theodor, A., 2011. Mol Pain. 7, 38.
Litschig, S., et al. 1999. Mol. Pharmacol. 55, 453.
Annoura, H., et al. 1996. Bioorg. Med. Chem. Lett. 6, 763.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-July-2013 JSW
Synonyms(E)-Ethyl 1,1a,7,7a-tetrahydro-7-(hydroxyimino)cyclopropa[b]chromene-1a-carboxylate, mGlu₁ Antagonist, CPCCOEt
DescriptionA potent, negative allosteric modulator selective for mGlu1 receptors (IC50 = 6.5 µM). No effect on other mGlu subtype receptors and ionotropic glutamate receptors at concentrations less than 100 µM. Acts by inhibiting an intramolecular interaction between the agonist-bound extracellular domain and the transmembrane domain. Widely used for studies related to peripheral pain and central pain pathways.
FormWhite powder
CAS number179067-99-3
Chemical formulaC₁₃H₁₃NO₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLuongo L, et al. 2013. Neuropharmacol. 66, 317.
Jin, Y., et al. 2012. Pain Res. Treat. 2012, 915706.
Tappe-Theodor, A., 2011. Mol Pain. 7, 38.
Litschig, S., et al. 1999. Mol. Pharmacol. 55, 453.
Annoura, H., et al. 1996. Bioorg. Med. Chem. Lett. 6, 763.