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504522 CNS-1102 - CAS 137159-92-3 - Calbiochem

CNS-1102 - CAS 137159-92-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NMDA Antagonist V, N-(3-Ethylphenyl)-N-methyl-N’-1-naphthalenylguanidine hydrochloride, Cerestat, Aptiganel hydrochloride

Primary Target: NMDA receptors
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
137159-92-3C₂₀H₂₁N₃ • HCl

Products

Catalog NumberPackaging Qty/Pack
5.04522.0001 Glass bottle 10 mg
Description
OverviewA non-competitive, subunit non-selective, potent antagonist for NMDA receptors (IC50 = 0.13, 0.068, 0.087, and 0.14 µM for NR2A - D, respectively). Widely used as neuroprotective agent after acute traumatic brain injury and stroke in animal researches.
Catalogue Number504522
Brand Family Calbiochem®
SynonymsNMDA Antagonist V, N-(3-Ethylphenyl)-N-methyl-N’-1-naphthalenylguanidine hydrochloride, Cerestat, Aptiganel hydrochloride
References
ReferencesReddy, N., et al. 1994. J. Medicinal Chemistry. 37, 260.
Muir, K., et al. 1994. British J. Clinical Pharmacol. 38, 33.
Schäbitz, W., et al. 2000. Stroke. 31, 1709.
Hoyte, L., et al. 2004. Current Molecular Medicine. 4, 131.
Turner, R., et al. 2013. J. of Neurosurgery. 1, 14.
Product Information
CAS number137159-92-3
FormWhite solid
FormulationSupplied as a hydrochloride salt.
Hill FormulaC₂₀H₂₁N₃ • HCl
Chemical formulaC₂₀H₂₁N₃ • HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNMDA receptors
Primary Target IC<sub>50</sub>0.13, 0.068, 0.087, and 0.14 µM for NR2A –D, respectively.
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number GTIN
5.04522.00014055977263732

Documentation

CNS-1102 - CAS 137159-92-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Reddy, N., et al. 1994. J. Medicinal Chemistry. 37, 260.
Muir, K., et al. 1994. British J. Clinical Pharmacol. 38, 33.
Schäbitz, W., et al. 2000. Stroke. 31, 1709.
Hoyte, L., et al. 2004. Current Molecular Medicine. 4, 131.
Turner, R., et al. 2013. J. of Neurosurgery. 1, 14.

Brochure

Title
Pathways and Biomarkers of Glutamatergic Synapse Flyer
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-June-2013 JSW
SynonymsNMDA Antagonist V, N-(3-Ethylphenyl)-N-methyl-N’-1-naphthalenylguanidine hydrochloride, Cerestat, Aptiganel hydrochloride
DescriptionA non-competitive, subunit non-selective, potent antagonist for NMDA receptors (IC50 = 0.13, 0.068, 0.087, and 0.14 µM for NR2A - D, respectively). Widely used as neuroprotective agent after acute traumatic brain injury and stroke in animal researches.
FormWhite solid
FormulationSupplied as a hydrochloride salt.
CAS number137159-92-3
Chemical formulaC₂₀H₂₁N₃ • HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (17 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesReddy, N., et al. 1994. J. Medicinal Chemistry. 37, 260.
Muir, K., et al. 1994. British J. Clinical Pharmacol. 38, 33.
Schäbitz, W., et al. 2000. Stroke. 31, 1709.
Hoyte, L., et al. 2004. Current Molecular Medicine. 4, 131.
Turner, R., et al. 2013. J. of Neurosurgery. 1, 14.